Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.050 Biomarker disease BEFREE Overall, there were 4% complete response (CR), 13% partial response (PR), 39% stable disease (SD), and 43% progressive disease (PD) with HD IL-2. 27916626 2017
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.050 Biomarker disease BEFREE Additionally, patients with a complete or partial response to high dose interleukin-2 had similar outcomes for subsequent targeted agents compared to patients whose best response was stable or progressive disease (median overall survival 30.1 vs 25.4 months, p = 0.4). 28288839 2017
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.050 Biomarker disease BEFREE In vitro cultured gammadelta T cells can be shown to upregulate the expression of CD16 in response to inflammatory cytokines such as IL-2 and -15, that have been shown to be elevated in progressive disease. 18155780 2008
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.050 Biomarker disease BEFREE Th1 or Type 1 cytokines, interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) are generally associated with resistance to infection, whereas Th2 or Type 2 cytokines, IL-4 and IL-10 are associated with progressive disease. 7713551 1994
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.050 Biomarker disease BEFREE Two of these patients exhibited stable disease after the interleukin-2 therapy and two exhibited progressive disease. 1511423 1992