Among the family members, the <i>Cib1</i> and <i>Cib2</i> genes are expressed in mouse cochlear hair cells, and mutations in the human <i>CIB2</i> gene have been associated with nonsyndromic deafness DFNB48 and syndromic deafness USH1J.
Here, we report that mutations in CIB2, which encodes a calcium- and integrin-binding protein, are associated with nonsyndromic deafness (DFNB48) and Usher syndrome type 1J (USH1J).