| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | disease | BEFREE | Here we identify that PPAR-γ expression in AM is crucial to suppress pulmonary inflammation and diseases and to promote fast host recovery from IAV and RSV infections. | 30787149 | 2019 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Moreover, we found that PPARγ activation not only inhibited CS/LPS-induced TLR2/4 expression and <i>miR-27-3p</i>-mediated TLR2/4 signaling cascades involving the nuclear factor-κB (NF-κB), c-Jun NH<sub>2</sub>-terminal kinase (JNK)/p38, and Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathways in AMs but also ameliorated CS/LPS-induced AM activation and pulmonary inflammation. | 29572385 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Rosiglitazone induces HO-1 expression via either NOX/ROS/c-Src/Pyk2/Akt-dependent Nrf2 activation or PPARγ in HPAEpiCs and suppresses LPS-mediated inflammatory responses, suggesting that PPARγ agonists may be useful for protection against pulmonary inflammation. | 30088830 | 2018 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Curcumin Attenuates Pulmonary Inflammation in Lipopolysaccharide Induced Acute Lung Injury in Neonatal Rat Model by Activating Peroxisome Proliferator-Activated Receptor γ (PPARγ) Pathway. | 29480285 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | We used 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) in a human model of lung inflammation to assess whether pioglitazone, a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, and zileuton, a 5-lipoxygenase inhibitor, reduce lung inflammation. | 29414995 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | PPARγ in dendritic cells and T cells drives pathogenic type-2 effector responses in lung inflammation. | 28798029 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | Both PPAR-γ and Nrf-2 might have benefits against lung inflammation. | 24865672 | 2014 | ||||
|
0.080 | Biomarker | disease | BEFREE | Conditional knockout of PPARγ in APCs using Cd11c-Cre Pparg(flox/flox) mice led to spontaneous lung inflammation and emphysema that resembled the phenotype of smoke-exposed mice. | 24569375 | 2014 |