Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 AlteredExpression disease BEFREE Multiple lines of evidence suggest that the excessive activation of Toll-like receptor 4 (TLR4) plays an important role in this detrimental lung inflammation. 30597258 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE PA LPS is recognized by Toll-like receptors-4 (TLR4) and has been shown to induce lung inflammation in vivo. 29547450 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE In conclusion, the results demonstrated that forsythoside B protects against LPS-induced ALI by attenuating inflammatory cell infiltration and suppressing TLR4/NF-κB-mediated lung inflammation. 30521962 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE Schaftoside, a natural flavonoid compound and a promising treatment for inflammation, has demonstrated potency against LPS-induced lung inflammation in mice; however, its action on TLR4-induced neuroinflammation and mitochondrial dynamics in microglia is still unknown. 30528467 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE Systemic release of high mobility group box 1, a TLR4 agonist, during the pneumonitis phase of the radiation response may act through TLR4 to contribute to fibroblast apoptosis resistance and thus interfere with wound resolution. 31020321 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE Toll-Like Receptor 4 (TLR-4) Pathway Promotes Pulmonary Inflammation in Chronic Intermittent Hypoxia-Induced Obstructive Sleep Apnea. 30293084 2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 AlteredExpression disease BEFREE We hypothesize that cigarette smoke adversely affects cholesterol transport via an ABCA1-dependent mechanism in macrophages, enhancing TLR4/myeloid differentiation primary response gene 88 (Myd88) signaling and resulting in matrix metalloproteinase (MMP) up-regulation and exacerbation of pulmonary inflammation. 29906247 2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE Compared with wild-type (WT) mice, CS-induced pulmonary inflammation was unaltered in TLR2-deficient ( Tlr2<sup>-/-</sup>) and TLR4-deficient ( Tlr4<sup>-/-</sup>) mice. 29025711 2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE The triggering receptor expressed by myeloid cells-1 activates TLR4-MyD88-NF-κB-dependent signaling to aggravate ventilation-induced lung inflammation and injury in mice. 29869715 2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE The ventilated rats pre‑treated with anti‑TLR4 mAb exhibited markedly attenuated signs of ventilation‑induced injury, such as less lung inflammation and pulmonary edema, fewer cells in BALF, and lower levels of ILs and TNF‑α in BALF and plasma. 28204830 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE Growing sets of data from in vitro and in vivo models demonstrate the role of the innate immune system, especially Toll-like receptor 4 (TLR4) and TLR9, in lung inflammation induced following exposure to contaminants in agricultural environments. 28168324 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE Taken together, these results suggest that GOH treatment alleviates LPS-induced ALI via inhibiting pulmonary inflammation and apoptosis, a finding that might be associated with the inhibition of TLR4-mediated NF-κB and Bcl-2/Bax signalling pathways. 29050341 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE HMGB1 translocation and release mediate cigarette smoke-induced pulmonary inflammation in mice through a TLR4/MyD88-dependent signaling pathway. 27807045 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease CTD_human Desert dust induces TLR signaling to trigger Th2-dominant lung allergic inflammation via a MyD88-dependent signaling pathway. 26882889 2016
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE We hypothesized that TLR4-mediated pulmonary inflammation may contribute to development of ALI during OLT. 26491225 2015
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE Alternatively spliced myeloid differentiation protein-2 inhibits TLR4-mediated lung inflammation. 25576596 2015
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 AlteredExpression disease BEFREE Thus, caveolin-1 Y14 phosphorylation was required for the interaction with TLR4 and activation of TLR4-MyD88 signaling and sepsis-induced lung inflammation. 24244013 2013
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE A TLR4-interacting SPA4 peptide inhibits LPS-induced lung inflammation. 23475791 2013
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE The innate immunity gene, toll-like receptor 4 (TLR4), protects against chronic pulmonary inflammation and tumorigenesis in mice, but the mechanism is unclear. 19925653 2009
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE Quite surprisingly, the absence of TLR4 greatly diminished pulmonary inflammation and the same phenotype was observed in PAFR-/- animals. 18292574 2008
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.400 Biomarker disease BEFREE A similar challenge with Hsp72 in TLR4 mutant mice did not stimulate the inflammatory response, stressing the importance of TLR4 in Hsp72-mediated lung inflammation. 17947709 2007