| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | phenotype | BEFREE | We performed a meta-analysis to assess the relationship between single nucleotide polymorphisms in the TNF-α promoter region (rs1800629 and rs361525) and susceptibility to squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and melanoma. | 28881857 | 2017 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | TNF was increased in SCC compared to normal skin.BCC showed increased IFNγ. hBD1, hBD2 and psoriasin mRNA and protein expression were significantly higher in SCC than in normal skin and higher than in BCC. | 22808251 | 2012 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | The tumor necrosis factor alpha -238 SNP and the interleukin 10 -1082 SNP were more prevalent in aggressive BCC. | 20489570 | 2010 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | We could now demonstrate that Gli2 gene silencing in BCC tissues made the tumor sensitive to TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated cell death by downregulating cFlip. | 18264131 | 2008 | ||||
|
0.080 | AlteredExpression | phenotype | BEFREE | The aim of the present study was to investigate the mRNA expression of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and IL-8 in biopsy specimens of basal cell carcinoma (BCC), and to compare the results with the mRNA levels of non-lesional skin of BCC patients and healthy subjects. | 16826314 | 2006 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | Further studies of other polymorphisms of the TNF-alpha gene associated with increased TNF-alpha production and BCC and necessary. | 14714556 | 2003 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | We determined whether the multiple cluster MPP was associated with characteristics associated with sensitivity to UV or glutathione S-transferase (GST) GSTT1, GSTM1, cytochrome P450 (CYP) CYP2D6, tumour necrosis factor (TNF)-alpha and vitamin D receptor (VDR) genotypes previously associated with BCC presentational phenotypes. | 11337940 | 2001 | ||||
|
0.080 | GeneticVariation | phenotype | BEFREE | These preliminary data provide the first evidence that TNF microsatellite polymorphism may influence the pathogenesis of multiple BCC. | 10735947 | 2000 |