Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 181
Gene Symbol: AGRP
AGRP
0.100 Biomarker disease BEFREE <b>Abbreviations</b>: ART, antiretroviral therapy; CI, confidence interval; Hib, <i>Haemophilus influenza</i> type b; HIV, human immunodeficiency virus; HIV+PCV-, HIV-infected, placebo-vaccinated group; HIV+PCV+, HIV-infected, PCV9-vaccinated group; HIV-PCV-, HIV-uninfected, placebo-vaccinated group; HIV+PCV+, HIV-infected, PCV9-vaccinated group; IBI, invasive bacterial infection; IPD, invasive pneumococcal disease; IRR, incidence rate ratio; IQR, interquartile range; OR, odds ratio; PCV, pneumococcal conjugate vaccine; PCV7, 7-valent pneumococcal conjugate vaccine; PCV9, 9-valent pneumococcal conjugate vaccine; PY, person-years; RCT, randomised control trial. 31156062 2020
Entrez Id: 9048
Gene Symbol: ARTN
ARTN
0.100 Biomarker disease BEFREE <b>Abbreviations</b>: ART, antiretroviral therapy; CI, confidence interval; Hib, <i>Haemophilus influenza</i> type b; HIV, human immunodeficiency virus; HIV+PCV-, HIV-infected, placebo-vaccinated group; HIV+PCV+, HIV-infected, PCV9-vaccinated group; HIV-PCV-, HIV-uninfected, placebo-vaccinated group; HIV+PCV+, HIV-infected, PCV9-vaccinated group; IBI, invasive bacterial infection; IPD, invasive pneumococcal disease; IRR, incidence rate ratio; IQR, interquartile range; OR, odds ratio; PCV, pneumococcal conjugate vaccine; PCV7, 7-valent pneumococcal conjugate vaccine; PCV9, 9-valent pneumococcal conjugate vaccine; PY, person-years; RCT, randomised control trial. 31156062 2020
Entrez Id: 171558
Gene Symbol: PTCRA
PTCRA
0.010 GeneticVariation disease BEFREE <b>Results:</b> Sensorineural hearing loss in the higher frequencies is a common form of hearing loss in HIV infected individuals throughout disease progression, along with decreased otoacoustic emission (OAE) responses, increased PTA hearing thresholds and prolonged latencies for auditory brainstem responses (ABR). 31447765 2019
Entrez Id: 2160
Gene Symbol: F11
F11
0.010 GeneticVariation disease BEFREE <b>Results:</b> Sensorineural hearing loss in the higher frequencies is a common form of hearing loss in HIV infected individuals throughout disease progression, along with decreased otoacoustic emission (OAE) responses, increased PTA hearing thresholds and prolonged latencies for auditory brainstem responses (ABR). 31447765 2019
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.020 Biomarker disease BEFREE (2008) report that the human immunodeficiency virus (HIV) transactivator Tat inhibits the SIRT1 deacetylase, resulting in increased acetylation of the NF-kappaB p65 subunit and subsequently in T cell hyperactivation. 18342601 2008
Entrez Id: 6857
Gene Symbol: SYT1
SYT1
0.010 Biomarker disease BEFREE (2008) report that the human immunodeficiency virus (HIV) transactivator Tat inhibits the SIRT1 deacetylase, resulting in increased acetylation of the NF-kappaB p65 subunit and subsequently in T cell hyperactivation. 18342601 2008
Entrez Id: 5970
Gene Symbol: RELA
RELA
0.010 Biomarker disease BEFREE (2008) report that the human immunodeficiency virus (HIV) transactivator Tat inhibits the SIRT1 deacetylase, resulting in increased acetylation of the NF-kappaB p65 subunit and subsequently in T cell hyperactivation. 18342601 2008
Entrez Id: 65125
Gene Symbol: WNK1
WNK1
0.010 Biomarker disease BEFREE (2008) report that the human immunodeficiency virus (HIV) transactivator Tat inhibits the SIRT1 deacetylase, resulting in increased acetylation of the NF-kappaB p65 subunit and subsequently in T cell hyperactivation. 18342601 2008
Entrez Id: 64689
Gene Symbol: GORASP1
GORASP1
0.010 Biomarker disease BEFREE (2008) report that the human immunodeficiency virus (HIV) transactivator Tat inhibits the SIRT1 deacetylase, resulting in increased acetylation of the NF-kappaB p65 subunit and subsequently in T cell hyperactivation. 18342601 2008
Entrez Id: 10599
Gene Symbol: SLCO1B1
SLCO1B1
0.020 GeneticVariation disease BEFREE * A single nucleotide polymorphism (SNP) in the SLCO1B1 gene (521T-->C) was associated with plasma levels of lopinavir in HIV-infected individuals. 20078617 2010
Entrez Id: 56477
Gene Symbol: CCL28
CCL28
0.010 GeneticVariation disease BEFREE * CDC recently evaluated the evidence and the updated WHO guidance on the risk for human immunodeficiency virus (HIV) acquisition among women using hormonal contraception.<sup>†</sup> After careful review, CDC adopted the updated WHO guidance for inclusion in the U.S. MEC guidance; this guidance states that the advantages of progestin-only injectable contraceptive use (including depot medroxyprogesterone acetate [DMPA]) by women at high risk for HIV infection outweigh the theoretical or proven risks (U.S. MEC category 2). 28934178 2017
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
0.010 Biomarker disease BEFREE 18F-FDG Uptake in Subcutaneous Fat Preceding Clinical Diagnosis of Human Immunodeficiency Virus-Associated Lipodystrophy. 30325831 2018
Entrez Id: 3930
Gene Symbol: LBR
LBR
0.030 AlteredExpression disease BEFREE 4-1BB expression was readily inducible on PHA stimulation of T cells from HIV-1-infected individuals. 9491912 1998
Entrez Id: 940
Gene Symbol: CD28
CD28
0.070 Biomarker disease BEFREE 4-1BB signal cooperated with CD28 for proper HIV-1+ CD4+ T cell proliferation. 9491912 1998
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.100 Biomarker disease BEFREE 4DV3 conjugated probes inhibited HIV-1 entry into the CXCR4-expressing reporter cell line TZM-bl (IC<sub>50</sub> at 553 nM) whereas 1DV3 and 2DV3 did not. 29894816 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.010 Biomarker disease BEFREE : Erythrina</i>; ERα/β: Estrogen receptors α/β; EtOAc: Ethyl acetate; EtOH: Ethanol; Hep-G2: Human liver carcinoma cell lines; HIV: Human immunodeficiency virus; HL-60: Human promyelocytic leukemia cells; K-562: Human immortalized myelogenous leukemia cell line; LPS: Lipopolysaccharide; MeOH: Methanol; MOLT-4: Acute lymphoblastic leukemia cell line; nAChRs: nicotinic acetylcholine receptors; NO: Nitric oxide; NREM: non-rapid eye movement; Pet. ether: Petroleum ether; RBA: Receptor binder affinity; TRAIL: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand. 31226894 2019
Entrez Id: 11261
Gene Symbol: CHP1
CHP1
0.100 Biomarker disease BEFREE Human immunodeficiency virus type 1 p24 concentration measured by boosted ELISA of heat-denatured plasma correlates with decline in CD4 cells, progression to AIDS, and survival: comparison with viral RNA measurement. 10751136 2000
Entrez Id: 928
Gene Symbol: CD9
CD9
0.100 Biomarker disease BEFREE Human immunodeficiency virus type 1 p24 concentration measured by boosted ELISA of heat-denatured plasma correlates with decline in CD4 cells, progression to AIDS, and survival: comparison with viral RNA measurement. 10751136 2000
Entrez Id: 11076
Gene Symbol: TPPP
TPPP
0.100 Biomarker disease BEFREE Human immunodeficiency virus type 1 p24 concentration measured by boosted ELISA of heat-denatured plasma correlates with decline in CD4 cells, progression to AIDS, and survival: comparison with viral RNA measurement. 10751136 2000
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE Human immunodeficiency virus type 1 p24 concentration measured by boosted ELISA of heat-denatured plasma correlates with decline in CD4 cells, progression to AIDS, and survival: comparison with viral RNA measurement. 10751136 2000
Entrez Id: 140767
Gene Symbol: NRSN1
NRSN1
0.100 Biomarker disease BEFREE Human immunodeficiency virus type 1 p24 concentration measured by boosted ELISA of heat-denatured plasma correlates with decline in CD4 cells, progression to AIDS, and survival: comparison with viral RNA measurement. 10751136 2000
Entrez Id: 115482709
Gene Symbol: H3P19
H3P19
0.100 Biomarker disease BEFREE Human immunodeficiency virus type 1 p24 concentration measured by boosted ELISA of heat-denatured plasma correlates with decline in CD4 cells, progression to AIDS, and survival: comparison with viral RNA measurement. 10751136 2000
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
0.070 Biomarker disease BEFREE Human immunodeficiency virus transactivator protein (Tat) stimulates chemotaxis, calcium mobilization, and activation of human polymorphonuclear leukocytes: implications for Tat-mediated pathogenesis. 11069235 2000
Entrez Id: 920
Gene Symbol: CD4
CD4
0.100 Biomarker disease BEFREE Human immunodeficiency virus type 1 (HIV-1) uses a coreceptor together with CD4 to enter CD4+ target cells. 11197206 2000
Entrez Id: 11076
Gene Symbol: TPPP
TPPP
0.100 Biomarker disease BEFREE Human immunodeficiency virus p24 antigen testing in cornea donors. 11322416 2001