Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE A second larger section covers the latest developments concerning nanomaterial-based biosensors for HIV diagnosis, with paying a special attention to the determination of CD4<sup>+</sup> cells as a hall mark of HIV infection, HIV gene, HIV p24 core protein, HIV p17 peptide, HIV-1 virus-like particles (VLPs) and HIV related enzymes, particularly those that are passed on from the virus to the CD<sup>4+</sup> T lymphocytes and are necessary for viral reproduction within the host cell. 31514868 2020
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 AlteredExpression disease BEFREE To investigate bPEI-induced cytotoxicity, we examined apoptosis and autophagy in cells treated with bPEI, and a significant increase in HIV viral load, the P24 antigen level, autophagy, and necrosis observed. 31598843 2019
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE We also inoculated HIV in vitro into AGW and control specimens from HIV-negative men and assessed infection by means of TZM-bl and p24 assays. 30137482 2019
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 AlteredExpression disease BEFREE The viral capsid protein p24 of human immunodeficiency virus is expressed at different level during viral invasion. 31519230 2019
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE The most probable explanation for her series of atypical HIV results is that the patient presented during the p24 seroconversion window, which is graphically conveyed in Figure 1. 31500995 2019
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE By simple physical linkage we were able to imprint this bias, exemplified by a low IgG2a/IgG1 ratio of antigen-specific antibodies, onto an unrelated antigen, namely the HIV capsid protein p24. 30781796 2019
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE A potassium hydroxide treatment followed by an equal ratio of 1% APTES and GLU attachment was found to be optimal, and a longer incubation with GLU favored maximum sensitivity. p24 is a vital early secreting antigen for diagnosing human immunodeficiency virus (HIV), and it has been used for efficient detection with the above chemistry. 30644016 2019
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE Hence, further testing by a nucleic acid test or a p24 antigen test of specimens reactive on screening with a fourth generation Ag/Ab assay that are negative on confirmatory testing for HIV-specific antibody, may be useful. 29928045 2018
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE Measurement of Human Immunodeficiency Virus p24 Antigen in Human Cerebrospinal Fluid With Digital Enzyme-Linked Immunosorbent Assay and Association With Decreased Neuropsychological Performance. 29385540 2018
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 AlteredExpression disease BEFREE Treatment of ACH-2 cells latently infected with HIV-1 with Cur-AgNP produced no toxic effects but significantly inhibited the expression of HIV-1 LTR (-73%, P < 0.01) and p24 (-57%, P < 0.05), IL-1βα (-61%, P < 0.01), TNF-αα (-54%, P < 0.05), IL-6 (-68%, P < 0.01), and NF-κB (-79%, P < 0.0001) as compared to untreated controls. 29058549 2017
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE To investigate the usefulness of rSmeg using pMyong2 in vaccine application, we vaccinated M. smegmatis with pMyong2 system expressing Human Immunodeficiency Virus Type I (HIV-1) Gag p24 antigen (rSmeg-pMyong2-p24) into mice and examined its cellular and humoral immune responses against HIV gag protein. 28300196 2017
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE Pretreatment and culture of PHA-blast target cells with BAGN increased the percentage of HIV-infected cells (7.6-fold, <i>p</i> = 0.0115), the per-cell amount of HIV p24 protein (1.3-fold, <i>p</i> = 0.2475), and the viral particles in culture supernatants (7.1-fold, <i>p</i> = 0.0029) compared to BAGN-free cultures. 29472913 2017
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE The Bio-Rad and Dia.Pro assays exhibited higher sensitivity for the detection of p24 antigen among the three fourth-generation HIV combination assays. 26433754 2017
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE We compared CV mucosal epithelial histology and immune cells, vaginal microbiota, antimicrobial activity of and soluble mucosal protein concentrations in the CV fluid lavage (CVL), and p24 antigen production after ex vivo infection of ectocervical tissues with HIV-1<sub>BaL</sub> among PRE women (n = 20) in the follicular and luteal phases of the menstrual cycle and POST women (n = 17) at baseline and after ∼1 month of treatment with 0.01% vaginal E2 cream. 28398069 2017
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE GSK3532795 is a second-generation human immunodeficiency virus type 1 (HIV-1) maturation inhibitor that targets HIV-1 Gag, inhibiting the final protease cleavage between capsid protein p24 and spacer protein-1, producing immature, noninfectious virions. 28369211 2017
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE Human immunodeficiency virus type 1 (HIV-1) p24 protein is the most abundant viral protein of HIV-1. 27069923 2016
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE After 3 years of individual-donation nucleic acid test (ID-NAT) screening by the South African National Blood Service (SANBS), a repository of 73 human immunodeficiency virus antibody (anti-HIV)-negative window period (WP)-yield samples and 28 anti-HIV-positive, HIV-RNA-negative elite controllers (ECs) became available for comparison of a p24 antigen (p24 Ag) assay (Innogenetics), two viral load assays (Siemens branch DNA [bDNA] 3.0 and Abbott real-time polymerase chain reaction [RT-PCR]), and three triplex NAT assays (Novartis Diagnostics Ultrio and Ultrio-Plus and Roche TaqScreen) by replicate testing of dilutions. 23445273 2013
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE All 4 miRNAs exhibited a significant inhibition of HIV-1 as measured by HIV-1 p24 enzyme-linked immunosorbent assay (>90%; P>0.001) when compared with the 3 negative controls. 20502318 2010
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE Clade-specific evolution mediated by HLA-B*57/5801 in human immunodeficiency virus type 1 clade A1 p24. 19759140 2009
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE We show here that CTL immunodominance in regions of the human immunodeficiency virus type 1 group-associated antigen proteins p17 and p24 correlated with epitope abundance, which was strongly influenced by proteasomal digestion profiles, affinity for the transporter protein TAP, and trimming mediated by the endoplasmatic reticulum aminopeptidase ERAAP, and was moderately influenced by HLA affinity. 19412183 2009
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE Several HIV-1 CD8(+) T cell escape variants were identified within maternal plasma viral p17 and p24 sequences that were either not detected or did not persist in the plasma of their non-HLA-matched HIV-1-infected infants. 18177249 2008
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles. 17494064 2007
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE Among the donors screened, two (one first-time and one repeat donor) were non-reactive in enzyme immunoassays, with negative confirmatory p24 antigen and Western blot, but positive for HIV-1 NAT. 17561863 2007
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 Biomarker disease BEFREE The diagnostic sensitivity of neopterin screening during the HIV window phase is similar to that of the p24 antigen test. 17076842 2006
Entrez Id: 10959
Gene Symbol: TMED2
TMED2
0.100 AlteredExpression disease BEFREE By using signal amplification of a heat-dissociated p24 antigen (p24Ag) assay, we compared p24Ag levels with levels of HIV RNA in plasma. 15071015 2004