Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 AlteredExpression disease BEFREE After 1 year of age, Ab levels to p31 and p17 were significantly associated with HIV-1 RNA levels (P < .001); Ab levels to gp160 (P < .001) and gp41 (P < .001) were significantly associated with cell-associated HIV-1 DNA levels. 30668843 2019
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 Biomarker disease BEFREE The mature envelope glycoprotein (Env) spike on the surfaces of human immunodeficiency virus type 1 (HIV-1)-infected cells and virions is derived from proteolytic cleavage of a trimeric gp160 glycoprotein precursor. 29618643 2018
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 GeneticVariation disease BEFREE The entry of human immunodeficiency virus (HIV-1) into host cells is mediated by the viral envelope glycoproteins (Envs), which are derived by the proteolytic cleavage of a trimeric gp160 Env precursor. 28151945 2017
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 Biomarker disease BEFREE This was achieved by replacing the single VSV glycoprotein (G) with human immunodeficiency virus type 1 (HIV-1) gp160 to create a hybrid fusion protein, gp160G. 26378177 2015
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 GeneticVariation disease BEFREE HIV-1 (human immunodeficiency virus type 1) uses its trimeric gp160 envelope (Env) protein consisting of non-covalently associated gp120 and gp41 subunits to mediate entry into human T lymphocytes. 24075869 2014
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 Biomarker disease BEFREE Host cell-mediated proteolytic cleavage of the human immunodeficiency virus type 1 (HIV-1) gp160 precursor glycoprotein into gp120 and gp41 subunits is required to generate fusion-competent envelope glycoprotein (Env) spikes. 24067980 2013
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 Biomarker disease BEFREE Patients included in a vaccine trial with recombinant HIV gp160 showed a 5-fold increase of EBV load compared to non-immunised patients and a 50-fold increase compared to healthy controls. 22863659 2012
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 Biomarker disease BEFREE The Human Immunodeficiency Virus type 1 (HIV-1) envelope glycoprotein gp160, useful in detecting anti-HIV-1 antibodies, is difficult to express in heterologous hosts. 23186021 2012
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 Biomarker disease BEFREE Furthermore, pGp120Ig significantly reduced the viral load after challenge with an HIV Env gp160-expressing vaccinia virus. 20566393 2010
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 Biomarker disease BEFREE Forty healthy volunteers were injected with DNA plasmids containing gp160 of HIV-1 subtypes A, B, and C; rev B; p17/p24 gag A and B, and RTmut B by use of a needle-free injection system. 18808335 2008
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 AlteredExpression disease BEFREE Nine (8%) of the 115 HIV-1-exposed, uninfected infants had detectable levels of HIV-1 gp160-specific IgA compared with four (13%) of 30 infected infants and none of 55 control infants (P = 0.47 and P = 0.03 respectively). 18505437 2008
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 GeneticVariation disease BEFREE Canarypox or vaccinia vaccine recipients' serum with or without HIV envelope glycoprotein (gp120 or gp160) boosts accounted for all positive Western blot results; no positive Western blot results were obtained from gp120 subunit recipients. 12660933 2003
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 Biomarker disease BEFREE Effect of the V3 loop deletion of envelope glycoprotein on cellular responses and protection against challenge with recombinant vaccinia virus expressing gp160 of primary human immunodeficiency virus type 1 isolates. 11932387 2002
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 Biomarker disease BEFREE Safety and immunogenicity of ALVAC vCP1452 and recombinant gp160 in newly human immunodeficiency virus type 1-infected patients treated with prolonged highly active antiretroviral therapy. 11836398 2002
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 Biomarker disease BEFREE By use of a third-generation native HIV(IIIB) gp160 enzyme immunoassay (EIA), detection of HIV antibodies occurred, on average, 33 days earlier than did detection by commercial EIA and 25 days earlier than did detection by the reference antigen and reverse-transcription polymerase chain reaction (RT-PCR) assays in 3 of 5 HIV seroconversion panels. 12134228 2002
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 GeneticVariation disease BEFREE Analysis of human immunodeficiency virus type 1 gp160 sequences from a patient with HIV dementia: evidence for monocyte trafficking into brain. 10871768 2000
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 Biomarker disease BEFREE Transduction of the MT-2 human T cell line with this vector rendered it resistant to infection with HIV-1 by a process that involved the inhibition of gp160 proteolytic processing. 9650619 1998
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 Biomarker disease BEFREE Cellular immune responses to human immunodeficiency virus type 1 (HIV-1) antigens, microbial recall antigens, and CD3 monoclonal antibody were studied in HIV-1-infected asymptomatic patients in a phase II, double-blind trial of immunization with recombinant HIV-1 gp160 in or not in association with zidovudine. 9333148 1997
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 Biomarker disease BEFREE In an effort to predict the efficacy of vaccination we have compared the systemic anti-envelope antibody response in seronegative volunteers immunized with recombinant gp160 (either in vaccinia or as soluble protein produced in baculovirus) derived from the HTLV-IIIB strain of HIV-1 and in two laboratory workers accidentally infected with the same strain. 7683694 1993
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 Biomarker disease BEFREE We report here the binding and transporting of HIV-1 glycoprotein gp160 to lysosomes as a result of the expression of fusion genes consisting of soluble CD4 and lysosome targeting domains. 8370478 1993
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 Biomarker disease BEFREE Resistance to human immunodeficiency virus 1 infection of SCID mice reconstituted with peripheral blood leukocytes from donors vaccinated with vaccinia gp160 and recombinant gp160. 8460155 1993
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 Biomarker disease BEFREE The safety and immunogenicity of a human immunodeficiency virus type 1 (HIV-1) gp160 recombinant vaccinia virus (HIVAC-1e) vaccine was evaluated in vaccinia-naive, healthy adults at low risk for acquiring HIV-1 infection. 1353102 1992
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 GeneticVariation disease BEFREE Sera were obtained from 50 individuals infected with human immunodeficiency virus type 1 or from HIV-1-uninfected individuals before or after vaccination with recombinant gp160. 1742081 1991
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 Biomarker disease BEFREE The 2 vaccinia-naive subjects vaccinated with HIVAC-1e showed strong T-cell responses to homologous and heterologous strains of whole virus and to recombinant gp160 protein that remained detectable for over a year; antibodies to HIV envelope also developed in both. 1671940 1991
Entrez Id: 2028
Gene Symbol: ENPEP
ENPEP
0.100 GeneticVariation disease BEFREE Expression of membrane-associated and secreted variants of gp160 of human immunodeficiency virus type 1 in vitro and in continuous cell lines. 2841466 1988