|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G or A3G) is a cytidine deaminase that inhibits the replication of several viruses, such as human immunodeficiency virus-1, hepatitis B virus and hepatitis C virus.
|
30862444 |
2019 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
Viral infectivity factor (Vif) is one of the accessory protein of human immunodeficiency virus type I (HIV-1) that inhibits host defense factor, APOBEC3G (A3G), mediated viral cDNA hypermutations.
|
31685340 |
2019 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human APOBEC3G (A3G) inhibits the replication of human immunodeficiency virus-1 by deaminating cytidine at the 3'-end in the target motif 5'-CCC-3' in viral cDNA during reverse transcription.
|
31116511 |
2019 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
A well-studied mechanism is APOBEC3G restriction of human immunodeficiency virus type 1, which is counteracted by a virus-encoded degradation mechanism<sup>1-4</sup>.
|
30420783 |
2019 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
APOBEC3G/3A Expression in Human Immunodeficiency Virus Type 1-Infected Individuals Following Initiation of Antiretroviral Therapy Containing Cenicriviroc or Efavirenz.
|
30135687 |
2018 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
APOBEC3G (A3G), an anti-human immunodeficiency virus 1 factor, deaminates cytidines.
|
28905055 |
2018 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
It can inhibit human immunodeficiency virus type 1 (HIV-1) replication at multiple stages and interact with apolipoprotein-B-mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G or A3G), a member of the cytidine deaminase family that exerts potent inhibitory effects against HIV-1 infection.
|
29258557 |
2017 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
APOBEC3G restricts human immunodeficiency virus 1 (HIV-1) infection by creating hypermutations in proviral DNA, while HIV-1-encoded vif protein antagonizes such restriction by targeting APOBEC3G for degradation.
|
28098260 |
2017 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
APOBEC3G (A3G) is a human enzyme that inhibits human immunodeficiency virus type 1 (HIV-1) infectivity, in the absence of the viral infectivity factor Vif, through deoxycytidine deamination and a deamination-independent mechanism.
|
28928403 |
2017 |
|
APOBEC3G
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Contribution of APOBEC3G/F activity to the development of low-abundance drug-resistant human immunodeficiency virus type 1 variants.
|
26482266 |
2016 |
|
APOBEC3G
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
There were no differences in the basal mRNA expression of APOBEC3G, CFLAR, TRIM5α, LEDGF/p75, BST-2, or SAMHD1 in CD4(+) T lymphocyte- and monocyte-enriched populations among the three groups, and lower HBD-3 concentrations were observed in saliva from HIV-ART compared to HESN and HC.
|
26389741 |
2015 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
APOBEC3G belongs to a family of DNA cytosine deaminases that are involved in the restriction of a broad number of retroviruses including human immunodeficiency virus type 1 (HIV-1).
|
24361275 |
2014 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
The best characterized members of this family are APOBEC3G (A3G) and APOBEC3F (A3F) and their restriction of HIV.
|
23555255 |
2013 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that conjugation of NEDD8 to Cullin-5 by the NEDD8-conjugating enzyme UBE2F is required for HIV Vif-mediated degradation of the host restriction factor APOBEC3G (A3G).
|
23300442 |
2012 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
This body of work suggests that the role of A3G in HIV infection is more complex than heretofore appreciated and supports the hypothesis that HIV has evolved to exploit the action of this host factor.
|
22546055 |
2012 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
APOBEC3G-induced hypermutation of human immunodeficiency virus type-1 is typically a discrete "all or nothing" phenomenon.
|
22457633 |
2012 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
APOBEC3G/F as one possible driving force for co-receptor switch of the human immunodeficiency virus-1.
|
21573951 |
2012 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human immunodeficiency virus (HIV) encodes the Vif protein to evade human APOBEC3G; however, mouse retroviruses do not encode a Vif homologue, and it has not been understood how they evade mouse APOBEC3.
|
20702647 |
2010 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
APOBEC3G (hA3G) is a host inhibitor for human immunodeficiency virus, type 1 (HIV-1).
|
20363737 |
2010 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
Investigation of the mechanisms showed that TLR-3 activation resulted in the induction of type I interferon inducible antiviral factors, including APOBEC3G and tetherin, the newly identified anti-HIV cellular proteins.
|
20636339 |
2010 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we report a detailed examination of human APOBEC3 gene expression, focusing on APOBEC3G (A3G) and APOBEC3F (A3F), which are potent inhibitors of human immunodeficiency virus type 1 (HIV-1) infection but are suppressed by HIV-1 Vif.
|
19587057 |
2009 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human immunodeficiency virus (HIV) exploits this 'window of opportunity' provided by the loss of LMM A3G in activated CD4 T cells to productively infect these cells.
|
19008196 |
2009 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
Reassessing the role of APOBEC3G in human immunodeficiency virus type 1 infection of quiescent CD4+ T-cells.
|
19300495 |
2009 |
|
APOBEC3G
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The Vif protein of wild-type HIV-1 counteracts APOBEC3G activity by targeting it for degradation and inhibiting its incorporation into viral particles.
|
18550667 |
2008 |
|
APOBEC3G
|
0.100 |
Biomarker
|
disease |
BEFREE |
APOBEC3G (A3G) is a cytidine deaminase that restricts human immunodeficiency virus type 1 (HIV-1) replication.
|
18684817 |
2008 |