Gene: STAT3 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 AlteredExpression disease BEFREE IL-6 induces haptoglobin expression through activating STAT3 in human head and neck cancer. 31478236 2020
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 Biomarker disease BEFREE STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer. 30863843 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 AlteredExpression disease BEFREE Combined modality radiation therapy promotes tolerogenic myeloid cell populations and STAT3-related gene expression in head and neck cancer patients. 29541413 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 Biomarker disease BEFREE Inhibition of JAK2/STAT3 reduces tumor-induced angiogenesis and myeloid-derived suppressor cells in head and neck cancer. 29215754 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 Biomarker disease BEFREE High Content Imaging Assays for IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines. 29082496 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 Biomarker disease BEFREE Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer. 25982282 2016
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 Biomarker disease BEFREE Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer. 27855189 2016
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 Biomarker disease BEFREE Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer. 26267899 2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 Biomarker disease BEFREE Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer. 24395800 2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 AlteredExpression disease BEFREE Cyclization of the STAT3 decoy markedly increased its half-life while preserving specificity and showed significant antitumor activity upon systemic delivery in preclinical models of head and neck cancer. 22886660 2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 PosttranslationalModification disease BEFREE Clinically, STAT3 phosphorylation was associated with head and neck cancer progression, EGFR phosphorylation, and heparanase expression and cellular localization. 22194600 2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 AlteredExpression disease BEFREE GS inhibited the activation of NF-κB and STAT3 proteins in head and neck cancer cells. 21177768 2011
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 AlteredExpression disease BEFREE In head and neck cancer both STAT1 and STAT3 are overexpressed. 22110204 2011
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 Biomarker disease BEFREE Absence of STAT1 disturbs the anticancer effect induced by STAT3 inhibition in head and neck carcinoma cell lines. 19424608 2009
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 Biomarker disease BEFREE Taken together, our data suggest, for the first time, a specific inhibitory effect of sulindac on tumor growth and survivin expression in laryngeal cancer, both in vitro and in vivo, in a Stat3-dependent manner, suggesting a novel therapeutic approach to head and neck cancer. 17401459 2007
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 Biomarker disease BEFREE Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer. 16505101 2006
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 Biomarker disease BEFREE STAT3 as a therapeutic target in head and neck cancer. 16503733 2006
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 Biomarker disease BEFREE Treatment of head and neck cancer cells with the Stat3 decoy inhibited proliferation and Stat3-mediated gene expression, but did not decrease the proliferation of normal oral keratinocytes. 12640143 2003
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 Biomarker disease BEFREE The roles of JNK1 and Stat3 in the response of head and neck cancer cell lines to combined treatment with all-trans-retinoic acid and 5-fluorouracil. 11927016 2002
Entrez Id: 6774
Gene Symbol: STAT3
STAT3 		0.100 AlteredExpression disease BEFREE To determine the timing of Stat3 activation in head and neck carcinogenesis, we studied the expression and constitutive activation of Stat3 in tumors and normal mucosa from patients with head and neck cancer compared with mucosa from controls without cancer. 10760290 2000