| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Moreover, stratified analyses indicated statistically significant associations between HLA-DRB1*04 allele and anti-cyclic peptides antibodies positivity (ACPA(+)) and rheumatoid factor positivity (RF(+); p(c)=0.03, for both subgroups), HLA-DRBI*10 and ACPA(+) and the presence of another autoimmune disease (p(c)=0.05 and p(c)=0.007, respectively), and HLA-DRB1*04:05 and RF(+) and erosion (p(c)=0.005 and p(c)=0.049; respectively). | 22349877 | 2012 | ||||
|
0.080 | Biomarker | disease | BEFREE | Rheumatoid factor positivity and bone erosion were more frequent in patients with at least one copy of DRB1*0405. | 17309132 | 2007 | ||||
|
0.080 | Biomarker | disease | BEFREE | Antibodies against cyclic citrullinated peptide are associated with the DRB1 shared epitope and predict joint erosion in rheumatoid arthritis. | 16728439 | 2007 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | HLA-DRB1* alleles and temporomandibular joint erosion in patients with various rheumatic diseases. | 15124939 | 2004 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | HLA-DRB1 alleles did not show any association with seropositivity, extra-articular involvement, radiological erosion, or functional index. | 14690140 | 2003 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | To assess the association between HLA-DRB1 alleles and shoulder destruction due to rheumatoid arthritis (RA) in Japanese, we typed for HLA-DRB1 alleles in 100 Japanese RA patients who could be classified into 5 groups: non-progressive (N) with normal radiographs; erosive (E) showing marginal erosion but no collapse; collapse (C) showing subchondral cysts followed by collapse; arthrosis-like (A) showing osteoarthrotic features; and the mutilating (M) showing mutilating bone destruction. | 9572642 | 1998 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | None of the DRB1 alleles or SE genotypes correlated with the presence of bone erosion at presentation or 1 year later. | 9416863 | 1997 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The results indicate that the most common RA susceptibility allele, HLA-DRB1*0405, is significantly associated with bony erosion, joint deformity and extra-articular manifestations. | 9159536 | 1997 |