Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 56955
Gene Symbol: MEPE
MEPE
0.330 AlteredExpression disease BEFREE Acquired syndromes of renal phosphate wasting, hypophosphatemia and osteomalacia (tumour-associated osteomalacia) can be due to the excessive synthesis or release of phosphaturic factors (FGF23, FGF-7, MEPE and sFRP4) from mesenchymal tumours. 25165185 2014
Entrez Id: 56955
Gene Symbol: MEPE
MEPE
0.330 Biomarker disease BEFREE We also compared the MEPE positivity of osteocytes in mineralized bone and non-mineralized osteoid obtained from patients with osteomalacia and osteoporosis. 15108058 2004
Entrez Id: 56955
Gene Symbol: MEPE
MEPE
0.330 Biomarker disease CTD_human Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. 11414762 2001
Entrez Id: 56955
Gene Symbol: MEPE
MEPE
0.330 AlteredExpression disease BEFREE MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. 10945470 2000
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 Biomarker disease BEFREE Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of certain mesenchymal tumors which secrete fibroblast growth factor-23 (FGF-23) responsible for causing features of hypophosphatemia and osteomalacia in these patients. 31744971 2020
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 Biomarker disease BEFREE In adults with X-linked hypophosphatemia (XLH), excess FGF23 impairs renal phosphate reabsorption and suppresses production of 1,25-dihydroxyvitamin D, resulting in chronic hypophosphatemia and persistent osteomalacia. 31369697 2019
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 Biomarker disease BEFREE Fibroblast Growth Factor 23 (FGF23) is a phosphaturic factor causing increased renal phosphate excretion as well as suppression of 1,25 (OH)<sub>2</sub>-vitamin D<sub>3.</sub> Highly elevated FGF23 can promote development of rickets and osteomalacia. 31628396 2019
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 Biomarker disease BEFREE X-linked hypophosphatemic rickets (XLHR) represents the most common form of genetic hypophosphatemia and causes rickets and osteomalacia in children because of increased FGF23 secretion and renal phosphate wasting. 30352126 2019
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 Biomarker disease BEFREE FGF23 excess and osteomalacia resolved only months after FCM discontinuation and aggressive phosphate repletion. 29298794 2018
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 GeneticVariation disease BEFREE X-linked hypophosphataemia (XLH) is the most common heritable form of osteomalacia and rickets caused by a mutation in the phosphate regulating endopeptidase gene resulting in elevated serum fibroblast growth factor 23 (FGF23) and decreased renal phosphate reabsorption. 29344330 2018
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 GeneticVariation disease BEFREE Phosphaturic mesenchymal tumor without osteomalacia: additional confirmation of the "nonphosphaturic" variant, with emphasis on the roles of FGF23 chromogenic in situ hybridization and FN1-FGFR1 fluorescence in situ hybridization. 29514106 2018
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 GeneticVariation disease BEFREE The same effects were seen in rodent bone models <i>in vitro</i>, in which we also detected formation of a sKL complex with FGF23-FGFR and decreased <i>Phex</i> (gene responsible for X-linked hypophosphatemic rickets (XLH)/osteomalacia) expression. 29632215 2018
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 Biomarker disease BEFREE Excessive actions of FGF23 cause several types of FGF23-related hypophosphatemic rickets/osteomalacia. 27754732 2017
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 AlteredExpression disease BEFREE Sclerostin antibody (Scl-Ab) improves osteomalacia phenotype in dentin matrix protein 1(Dmp1) knockout mice with little impact on serum levels of phosphorus and FGF23. 26721590 2017
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 Biomarker disease BEFREE The high production of fibroblast growth factor 23 (FGF23) by the tumor is believed to be the causative factor responsible for the impaired renal tubular phosphate reabsorption, hypophosphatemia and osteomalacia. 28193220 2017
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 AlteredExpression disease BEFREE Owing to the role of FGF23 in renal phosphate handling and vitamin D synthesis, TIO is characterized by decreased renal tubular reabsorption of phosphate, by hypophosphataemia and by low levels of active vitamin D. Chronic hypophosphataemia ultimately results in osteomalacia (that is, inadequate bone mineralization). 28703220 2017
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 Biomarker disease BEFREE X-linked hypophosphatemia (XLH) caused by mutations in the Phex gene is the most common human inherited phosphate wasting disorder characterized by enhanced synthesis of fibroblast growth factor 23 (FGF23) in bone, renal phosphate wasting, 1,25(OH)<sub>2</sub>D<sub>3</sub> (1,25D) deficiency, rickets and osteomalacia. 28728941 2017
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 GeneticVariation disease BEFREE Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome in which unregulated hypersecretion of fibroblast growth factor 23 (FGF23) by phosphaturic mesenchymal tumors (PMT) causes renal phosphate wasting, hypophosphatemia, and osteomalacia. 28459498 2017
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 Biomarker disease BEFREE Loss of fibroblast growth factor-23 (FGF23) causes hyperphosphatemia, extraskeletal calcifications, and early mortality; excess FGF23 causes hypophosphatemia with rickets or osteomalacia. 27929669 2017
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 Biomarker disease BEFREE Compared to Hyp mice, compound Hyp;Fgfr1Dmp1-cKO-null mice had significant improvement in rickets and osteomalacia in association with a decrease in serum FGF23 (3607 to 1099 pg/ml), an increase in serum phosphate (6.0 mg/dl to 9.3 mg/dl) and 1,25(OH)2D (121±23 to 192±34 pg/ml) levels, but only a 30% reduction in bone FGF23 mRNA expression. 25089825 2014
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 AlteredExpression disease BEFREE Our finding of somatic activating RAS mutation in bone, the endogenous source of FGF23, provides the first evidence that elevated serum FGF23 levels, hypophosphatemia and osteomalacia are associated with pathologic Ras activation and may provide insight in the heretofore limited understanding of the regulation of FGF23. 24006476 2014
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 AlteredExpression disease BEFREE Acquired syndromes of renal phosphate wasting, hypophosphatemia and osteomalacia (tumour-associated osteomalacia) can be due to the excessive synthesis or release of phosphaturic factors (FGF23, FGF-7, MEPE and sFRP4) from mesenchymal tumours. 25165185 2014
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 AlteredExpression disease BEFREE Autosomal dominant hypophosphatemic rickets (ADHR) is a rare genetic disorder of phosphate homeostasis characterized, when severely expressed, by osteomalacia, suppressed levels of calcitriol, and renal phosphate wasting due to elevated levels of fibroblast growth factor 23 (FGF23). 23174215 2013
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 Biomarker disease BEFREE FGF23 was discovered as the humoral factor in tumors that causes hypophosphatemia and osteomalacia and through the identification of a mutant form of FGF23 that leads to autosomal dominant hypophosphatemic rickets (ADHR), a rare genetic disorder. 22396161 2012
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.200 Biomarker disease BEFREE X-linked hypophosphatemic rickets/osteomalacia (XLH), autosomal dominant hypophosphatemic rickets/osteomalacia (ADHR) and autosomal recessive hypophosphatemic rickets/osteomalacia (ARHR1 or ARHR2) are hereditary fibroblast growth factor 23 (FGF23)-related hypophosphatemic rickets showing similar clinical features. 21745613 2011