Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 28471
Gene Symbol: IGHV1-12
IGHV1-12
0.060 Biomarker disease BEFREE This included a germ cell tumor in 12 (30%) patients by the finding of i(12p), increased 12p copy number, or a deletion of the long arm of chromosome 12. 7799031 1995
Entrez Id: 28471
Gene Symbol: IGHV1-12
IGHV1-12
0.060 GeneticVariation disease BEFREE One or more copies of i(12p), excess 12p copy number, or a deletion on the long arm of chromosome 12 was found in seven of 28 (25%) midline tumors of uncertain histogenesis, thus establishing a diagnosis of a germ cell tumor in these patients. 8308927 1994
Entrez Id: 28471
Gene Symbol: IGHV1-12
IGHV1-12
0.060 Biomarker disease BEFREE Clonal relationship between the teratoma and rhabdomyosarcoma of the germ cell tumor was established by the presence in both of i(12p), the characteristic marker of germ cell tumors. 1676906 1991
Entrez Id: 28471
Gene Symbol: IGHV1-12
IGHV1-12
0.060 Biomarker disease BEFREE The metastatic yolk sac tumor had a hypertriploid karyotype and a DI of 1.78 and lacked the germ cell tumor marker i(12p). 2297683 1990
Entrez Id: 28471
Gene Symbol: IGHV1-12
IGHV1-12
0.060 Biomarker disease BEFREE In one case, two copies of the germ cell tumor marker i(12p) were found. 2331686 1990
Entrez Id: 28471
Gene Symbol: IGHV1-12
IGHV1-12
0.060 Biomarker disease BEFREE The most significant cytogenetic finding was the presence of the metacentric germ cell tumor marker i(12p) in an inguinal metastasis. 2766245 1989
Entrez Id: 174
Gene Symbol: AFP
AFP
0.050 AlteredExpression disease BEFREE Preoperative serum alpha-fetoprotein (AFP) levels were reviewed in germ cell tumor (GCT) cases and analyzed to predict malignancy in various age groups. 28967388 2017
Entrez Id: 174
Gene Symbol: AFP
AFP
0.050 Biomarker disease BEFREE The prognostic information provided by alpha-fetoprotein and human chorionic gonadotrophin in the management of germ cell tumor (GCT) patients is a biochemical reflection of tumor differentiation. 12860944 2003
Entrez Id: 174
Gene Symbol: AFP
AFP
0.050 Biomarker disease BEFREE By establishing sensitive nested reverse transcription-PCRs for the detection of mRNA of alpha-fetoprotein (AFP) and beta human chorionic gonadotropin (betahCG), we investigated the presence of circulating tumor cells in the peripheral blood of 119 patients with germ-cell tumor. 10866307 2000
Entrez Id: 174
Gene Symbol: AFP
AFP
0.050 Biomarker disease BEFREE Hereditary persistence of alpha-fetoprotein (HPAFP) should be considered in both children and adults with unexplained and persistent elevation of AFP e.g., those screened for hepatocellular carcinoma or diagnosed for germ cell tumor. 9681083 1998
Entrez Id: 174
Gene Symbol: AFP
AFP
0.050 Biomarker disease BEFREE We recommend that all males with KS and early sexual development or with "normal" testicular growth be screened with measurement of germ cell tumor markers including beta-subunit of human chorionic gonadotropin and alpha-fetoprotein. 7535510 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.030 GeneticVariation disease BEFREE By comparing candidate driving genes between AYA cancers and those from all age groups for the same type of cancer, we identified different driving genes in prostate cancer and a germ cell tumor in AYAs compared with all age groups, whereas three common alterations (TP53, FAT1, and NOTCH1) in head and neck cancer were identified in both groups. 26925973 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.030 AlteredExpression disease BEFREE Cluster analysis of p53 and Ki67 expression, apoptosis, alpha-fetoprotein, and human chorionic gonadotrophin indicates a favorable prognostic subgroup within the embryonal carcinoma germ cell tumor. 12860944 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.030 Biomarker disease BEFREE None of the remaining eight cases with frequent positive cells, the nine cases with occasionally positive p53 staining, or the two cases with no staining recurred or demonstrated other germ cell tumor elements. 12202994 2003
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.020 Biomarker disease BEFREE Successful hematopoietic stem cell mobilization with vinorelbine and filgrastim in germ cell tumor. 27165295 2017
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.020 Biomarker disease BEFREE To examine the impact of granulocyte-colony stimulating factor (G-CSF) use on the incidence and severity of bleomycin-induced pneumonitis (BIP) in patients with germ cell tumor (GCT) receiving first-line chemotherapy. 28943331 2017
Entrez Id: 6657
Gene Symbol: SOX2
SOX2
0.010 Biomarker disease BEFREE Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumor fate. 31583686 2020
Entrez Id: 64321
Gene Symbol: SOX17
SOX17
0.010 Biomarker disease BEFREE Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumor fate. 31583686 2020
Entrez Id: 3728
Gene Symbol: JUP
JUP
0.010 Biomarker disease BEFREE The most highly conserved gene set in this cross-species analysis included potential driver genes such as JUP, which we show to be essential for germ cell tumor cell growth. 31087453 2019
Entrez Id: 442916
Gene Symbol: MIR371A
MIR371A
0.010 AlteredExpression disease BEFREE Our objective was to evaluate operating characteristics, particularly specificity and positive predictive value (PPV), by mapping plasma miR371 expression to actual clinical events in patients with a history of germ cell tumor. 31553692 2019
Entrez Id: 7704
Gene Symbol: ZBTB16
ZBTB16
0.010 Biomarker disease BEFREE ZBTB16 effectively differentiates PNETs from other small round blue cell tumor mimics, including the two most common germ cell tumor-derived somatic malignancies - rhabdomyosarcoma and nephroblastoma. 31326195 2019
Entrez Id: 2719
Gene Symbol: GPC3
GPC3
0.010 AlteredExpression disease BEFREE Glypican 3 (GPC3) is a heparan sulfate proteoglycan and cell surface oncofetal protein which is highly expressed on a variety of pediatric solid embryonal tumors including the majority of hepatoblastomas, Wilms tumors, rhabdoid tumors, certain germ cell tumor subtypes, and a minority of rhabdomyosarcomas. 30873384 2019
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
0.010 Biomarker disease BEFREE Patients were evaluated based on the F-FDG PET/computed tomography indications and germ cell tumor subtypes. 31568190 2019
Entrez Id: 1442
Gene Symbol: CSH1
CSH1
0.010 Biomarker disease BEFREE From 1987 to 2001, DMC for CS I seminomatous germ cell tumor (SGCT) patients were EUR 13.790 ± 4.700. 29514158 2018
Entrez Id: 22883
Gene Symbol: CLSTN1
CLSTN1
0.010 Biomarker disease BEFREE From 1987 to 2001, DMC for CS I seminomatous germ cell tumor (SGCT) patients were EUR 13.790 ± 4.700. 29514158 2018