Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.540 Biomarker disease BEFREE In this report, we aimed to explore the roles of gene polymorphisms affecting x-ray repair cross complementing 1 (XRCC1), the tumor protein p53 (TP53), and fibroblast growth factor receptor 3 (FGFR3) in the context of susceptibility to cervical cancer. 30616520 2019
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.540 Biomarker disease BEFREE The frequency of FGFR3-TACC3-fusion-positive cervical cancer is also 1.9% (2/103) in an independent cohort. 29358619 2018
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.540 Biomarker disease BEFREE The research conducted in this article examines a frequently identified fusion protein between FGFR3 and transforming acidic coiled-coil containing protein 3 (TACC3), frequently identified in glioblastoma, lung cancer, bladder cancer, oral cancer, head and neck squamous cell carcinoma, gallbladder cancer, and cervical cancer. 26869289 2016
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.540 Biomarker disease BEFREE Fibroblast growth factor receptor-3 (FGFR3) is a receptor tyrosine kinase implicated in the tumorigenesis of multiple malignancies, including bladder and other urothelial cancers, multiple myeloma, and cervical cancer. 22285006 2013
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.540 GeneticVariation disease UNIPROT Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas. 10471491 1999
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.540 Biomarker disease CTD_human
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE Subgroup analyses based on race system showed that HLA-DPB1⁎13:01 was significantly associated with an increased risk of cervical cancer in Asia (OR=1.834, 95%CI: 1.107-3.039, Pz=0.019). 30009173 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.500 GeneticVariation disease BEFREE The liver kinase B1 (LKB1) gene is a tumor suppressor associated with the hereditary Peutz-Jeghers syndrome and frequently mutated in non-small cell lung cancer and in cervical cancer. 30222967 2018
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.500 GeneticVariation disease BEFREE However, the significance of LKB1 mutations in cervical cancer initiation and progress has not been examined. 27546620 2017
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE No association was detected between HLA-DPB1 alleles and cervical cancer risk in the Japanese population. 27193219 2016
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE We investigated whether polymorphisms in the HLA-DPB1 gene were associated with cervical cancer risk in a Taiwanese population. 26031576 2015
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE Our study provides the first systematic investigation of the association of genetic variants in the HLA-DP region with cervical cancer susceptibility and provides further insight into the contribution of polymorphisms in the HLA-DP region to risk of cervical cancer. 24743517 2014
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.500 Biomarker disease BEFREE Heightened and sustained receptor activation was demonstrated by LKB1-deficient A549 (lung) and HeLaS3 (cervical) cancer cell lines. 24285539 2014
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.500 AlteredExpression disease BEFREE Gene expression profiles of cervical cancer HeLa cells stably expressing LKB1 were analyzed by microarray. 24792998 2014
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.500 Biomarker disease BEFREE Mir-155 promotes cervical cancer cell proliferation through suppression of its target gene LKB1. 25155037 2014
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease GWASDB We additionally replicated an association between HLA-DPB1 and HLA-DPB2 (HLA-DPB1/2) at 6p21.32 and cervical cancer (rs4282438, Pcombined, stringently matched=4.52×10(-27), per-allele ORstringently matched=0.75). 23817570 2013
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE These findings indicate that HLA-DP rs3077 and rs9277535 were candidate susceptibility markers for cervical cancer in Chinese females. 23428460 2013
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 Biomarker disease CTD_human We additionally replicated an association between HLA-DPB1 and HLA-DPB2 (HLA-DPB1/2) at 6p21.32 and cervical cancer (rs4282438, Pcombined, stringently matched=4.52×10(-27), per-allele ORstringently matched=0.75). 23817570 2013
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.500 AlteredExpression disease BEFREE LKB1 expression and the integrity of LKB1-AMPK signaling were determined with immunoblot in 6 cervical cancer cell lines. 22735790 2012
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE The results illustrate the value of pathway-based analysis to mine genome-wide data, and point to the importance of the MHC region and specifically the HLA-DPB1 locus for susceptibility to cervical cancer. 21716314 2011
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.500 GeneticVariation disease BEFREE Mutations in the tumor suppressor gene LKB1 are important in hereditary Peutz-Jeghers syndrome, as well as in sporadic cancers including lung and cervical cancer. 21926085 2011
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.500 AlteredExpression disease BEFREE Thus, homozygous deletions affecting LKB1 in cervical cancers may generate multiple fusion transcripts involving LKB1, SBNO2, and c19orf26. 20193846 2010
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.500 GeneticVariation disease BEFREE Somatic LKB1 mutations promote cervical cancer progression. 19340305 2009
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.500 Biomarker disease BEFREE The LKB1 serine-threonine kinase is a tumor suppressor that is inactivated in a large number of sporadic human lung non-small cell carcinomas (NSCLCs) and cervical cancers. 19724060 2009
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1
0.500 GeneticVariation disease BEFREE D6S2766 and D6S2764, which are located near to the region containing the HLA-DPB genes, were negatively related with cervical cancer (OR for the D6S2766-195 allele carriers = 0.50), and positively related with cervical cancer (OR for the D6S2764-209 allele carriers = 2.44), respectively. 18712835 2008