Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 AlteredExpression disease BEFREE The encephalitis-positive case showed that (i) more dysplastic neuroglia with higher Ki-67 labeling index values than the control cases, which met the diagnostic criteria of astrocytoma, (ii) the NMDAR subunit NR1 was expressed more abundantly in neuroglial tissue where many neuroglial cells co-expressed glial fibrillary acidic protein (GFAP) and NR1 and formed abnormally large cellular masses, (iii) intense NR1 expression occurs in squamous epithelium near neuroglial tissue and lymphocyte infiltration. 31756658 2020
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 Biomarker disease BEFREE We suggest that discriminating between the GFAP isoforms GFAPδ and GFAPα will improve the accuracy of assessing the differentiation state of astrocytoma in clinical and experimental settings and will benefit glioma classification. 30667110 2019
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 Biomarker disease BEFREE Combination value of diffusion-weighted imaging and dynamic susceptibility contrast-enhanced MRI in astrocytoma grading and correlation with GFAP, Topoisomerase IIα and MGMT. 31452754 2019
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 AlteredExpression disease BEFREE As a result, <i>GFAP</i> mRNA and protein expression was found to be declining with increasing astrocytoma grade (p < 0.05). 30519355 2018
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 GeneticVariation disease BEFREE Several <i>GFAP</i> splice variants have been identified and the main variants expressed in human astrocytoma are the <i>GFAP</i>α and <i>GFAP</i>δ isoforms. 29152145 2017
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 AlteredExpression disease BEFREE To delineate the mechanism of action we assessed the role of HIV-Tat (present in the Tg rats) in inducing miRs-34a & -138 in both the primary astrocytes and the astrocytoma cell line A172, thereby leading to posttranscriptional suppression of SIRT1 with a concomitant up regulation of NF-kB driven expression of GFAP. 28236278 2017
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 GeneticVariation disease BEFREE Here the authors present an infant initially diagnosed with a chiasmatic astrocytoma that was later identified as having glial fibrillary acidic protein mutation-confirmed Alexander disease. 28112050 2017
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 AlteredExpression disease BEFREE Pathologic grade and expressions of glial fibrillary acidic protein (GFAP), Ki67 (proliferation marker), and FMRP were determined in astrocytoma specimens from 74 patients. 27683117 2016
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 Biomarker disease BEFREE A., Geerts, D., van Tijn, P., Wiche, G., van Strien, M. E., Hol, E. M. Silencing GFAP isoforms in astrocytoma cells disturbs laminin dependent motility and cell adhesion. 24696300 2014
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 AlteredExpression disease BEFREE Inhibition of histone deacetylases (HDACs) with trichostatin A or sodium butyrate reduced GFAP expression in primary human astrocytes and astrocytoma cells. 25128567 2014
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 Biomarker disease BEFREE Exome-NGS revealed a mutation in a previously neglected GFAP isoform, GFAP-ϵ, which disrupts the GFAP-associated filamentous cytoskeletal meshwork of astrocytoma cells. 23634874 2013
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 Biomarker disease BEFREE Transient transfection of N-GFAP into a human astrocytoma cell line induces the formation of cytoplasmic aggregates, which also disrupt the endogenous GFAP networks. 24102621 2013
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 GeneticVariation disease BEFREE On the basis of the protective role shown by both these small heat shock proteins (sHSPs), and on the already well established neuroprotective effects of curcumin in several diseases, we have investigated the effects of this compound in an in vitro model of Alexander disease, consisting in U251-MG astrocytoma cells transiently transfected with a construct encoding for GFAP carrying the p.R239C mutation in frame with the reporter green fluorescent protein (GFP). 22705585 2012
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 Biomarker disease BEFREE By characterizing the transcriptome and in vivo properties of 20 astrocytoma cell lines, we found that the levels of MMP2 were higher in GFAP(-) astrocytoma cells and correlated with their ability to induce vascular changes, a common complication of malignant tumours. 21462187 2011
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 Biomarker disease BEFREE In glial tumors, GFAP expression is frequently lost with increasing grade of malignancy, suggesting that GFAP is important for maintaining glial cell morphology or regulating astrocytoma cell growth. 21075782 2011
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 Biomarker disease BEFREE In this study, we reported concurrent up-regulation of adenovirus E1a-associated 300 kDa protein p300 and GFAP in Tat-expressing human astrocytoma cells and primary astrocytes. 20578042 2010
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 GeneticVariation disease BEFREE The process of inducing GFAP aggregates in astrocytoma-derived cells is different between R239C and R416W mutant GFAP. A time-lapse recording study. 19379794 2009
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 Biomarker disease BEFREE Retroviral gene trapping of nontransformed neonatal astrocytes from a glial fibrillary acidic protein (GFAP):(V12)Ha-Ras murine astrocytoma model led to isolation of the transcription factor Gata6. 17463088 2007
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 AlteredExpression disease BEFREE Compared to wild-type GFAP expression, RC GFAP expression lowered plectin levels in astrocytoma-derived stable transfectants and plectin-positive fibroblasts. 16507904 2006
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 Biomarker disease BEFREE To determine whether EGFR overexpression could modify the tumor phenotype in our previously reported GFAP-V(12)Ha-ras transgenic mouse astrocytoma model, mice expressing both activated RAS and EGFR were developed. 12615729 2003
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 AlteredExpression disease BEFREE p16(ink4a) and retinoic acid modulate rhoA and GFAP expression during induction of a stellate phenotype in U343 MG-A astrocytoma cells. 12237846 2002
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 Biomarker disease BEFREE We developed a transgenic mouse astrocytoma model using the glial fibrillary acidic protein (GFAP) promoter to express oncogenic V(12)Ha-ras, specifically in astrocytes. 11325859 2001
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 Biomarker disease BEFREE Measles virus-induced disruption of the glial-fibrillary-acidic protein cytoskeleton in an astrocytoma cell line (U-251). 10729162 2000
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 AlteredExpression disease BEFREE In the U-373 MG astrocytoma, mRNA expression of RAR beta was increased and GFAP was decreased by RA. 11058790 2000
Entrez Id: 2670
Gene Symbol: GFAP
GFAP
0.100 Biomarker disease BEFREE These results suggest that GFAP is a critical regulator of the tumor growth of astrocytoma. 9972884 1999