| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.100 | Biomarker | disease | BEFREE | A panel of monoclonal antibodies (MAbs) to P-glycoprotein was developed by immunization of mice with multidrug-resistant human neuroepithelioma and neuroblastoma cells. | 1348013 | 1992 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | Because expression of mdr-1 is increased in neuroblastoma cell lines by differentiating agents, the authors hypothesized a similar correlation with differentiation in vivo in neuroblastomas. | 1678252 | 1991 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | Many of the neuroblastoma samples were also evaluated for N-myc amplification but there was no correlation between N-myc copy number and the level of MDR1 mRNA expression. | 2295903 | 1990 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | MDR1 mRNA transcription may occur spontaneously after onset, suggesting that certain NB tumors could be resistant to antineoplastic drugs at onset. | 1974410 | 1990 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | The role, if any, of increased expression of mdr-1 in the acquisition of multidrug resistance in neuroblastoma remains unclear. | 2185879 | 1990 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | MDR1 RNA levels were occasionally elevated in other untreated cancers, including neuroblastoma, acute lymphocytic leukemia (ALL) in adults, acute nonlymphocytic leukemia (ANLL) in adults, and indolent non-Hodgkin's lymphoma. | 2562856 | 1989 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | The results indicate that the level of MDR1 mRNA expression is associated with previous chemotherapy, including drugs that select the multidrug resistance phenotype in vitro regardless of neuroblastoma tissue origin or N-myc content in the genome. | 2778826 | 1989 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | An increase in the level of mdr1 mRNA was observed after retinoic acid treatment of four neuroblastoma cell lines, including the SK-N-SH cell line. | 2573830 | 1989 |