Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 AlteredExpression disease BEFREE Neuroprotective effects were evaluated in a neurotoxic model induced by 6-hydroxydopamine (6-OHDA) in a human neuroblastoma cell line (SH-SY5Y), while the mechanisms associated to neuroprotection were investigated by the determination of mitochondrial membrane potential, H₂O₂ production, Caspase-3 activity, and by observation of DNA fragmentation. 30717087 2019
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE In conclusion, curcumin strongly induces modulator effects on TRPM2-mediated Ca<sup>2+</sup> influx caused by ROS and caspase 3 and 9 processes in SH-SY5Y neuroblastoma cells. 28569571 2019
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE Exposure of these NB cell lines to 100 μM of harmine resulted in caspase-3/7 and caspase-9 activation as well as caspase-mediated PARP cleavage and Annexin V-positive stained cells, as early as 24 h after treatment, clearly suggesting apoptosis induction, especially in <i>MYCN</i>-amplified cell lines. 29977157 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 AlteredExpression disease BEFREE OGD treatment significantly increased N2A cell death and Caspase-3 activity, and decreased Bcl-2 protein expression. 29715465 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE We have shown that targeting of the <i>Plaur</i> gene in mouse neuroblastoma Neuro 2A cells by CRISPR/Cas9n results in ~60% decrease in cell proliferation (p<0.05), reduction in the number of Ki-67 positive cells, caspase 3 activation and PARP-1 cleavage. 30034627 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE We exposed the human neuroblastoma-derived, SH-SY5Y cells to a relatively high concentration of EtOH (500 mM) for 24 h and evaluated the effects of two concentrations of DON (0.1 and 1.0 μM) on alcohol-induced toxicity and caspase-3, an apoptotic marker. 29804239 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 AlteredExpression disease BEFREE Bt2cAMP also upregulated miR-665, and miR665 transfection mimicked the effects of Bt2cAMP, including reduced c-MYC and HDAC8 expression, increased caspase 3 activation, and reduced neuroblastoma cell growth. 30237861 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE Consistently, we show that these mutations cause protein aggregation which are recognised by the autophagic pathway in motoneurons and triggered caspase 3 activation leading to apoptosis in neuroblastoma cells. 28709447 2017
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 AlteredExpression disease BEFREE The oligomer Aβ (5 μM) significantly increased the level of caspase 3 cleavage and has the ability to induce cytotoxicity in human neuroblastoma SK-N-MC cells. 28790888 2017
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE Treating four established NB cells lines (SMS-KCNR, SH-SY5Y, BE(2)-C, CHLA-90) and two primary NB cell lines with Tolcapone for 48 h decreased cell viability in a dose-dependent manner, with IncuCyte imaging and Western blotting indicating that cell death was due to caspase-3-mediated apoptosis. 28429453 2017
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE Activation of caspase 3 was also observed in xenografts of NB in nude mice upon combination of doxorubicin with the specific PI3K inhibitor PI103. 26224681 2016
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 AlteredExpression disease BEFREE We have recently shown that thymoquinone (TQ) has a potent cytotoxic effect and induces apoptosis via caspase-3 activation with down-regulation of XIAP in mouse neuroblastoma (Neuro-2a) cells. 26745078 2015
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE SsnB lowers the cellular level of glutathione (GSH), increases generation of reactive oxygen species and activates the cleavage of caspase-3 whereas co-incubation of a GSH precursor, N-acetylcysteine, along with SsnB attenuates the inhibitory effects of SsnB and increases the neuroblastoma cell viability. 24788776 2014
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE The present study demonstrated that treatment with 1-10 μg/ml tunicamycin, a potent revulsant of ER stress, drastically induced TXNIP expression accompanied by the generation of cleaved caspase-3 as an indicator of apoptosis in SK-N-SH human neuroblastoma cells. 23774476 2013
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE Here we show that low micromolar concentrations of zonisamide prevented cleavage of caspase-3 and cell death in human dopaminergic SH-SY5Y neuroblastoma cells that were subjected to endoplasmic reticulum stress induced by tunicamycin or 6-hydroxydopamine. 21892618 2012
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE We therefore investigated the role of IRS-1/-2 in glucose-induced caspase-3 activation using human neuroblastoma cells. 21354306 2011
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE We found that doxycycline prevents Aβ fibrillization and favors the generation of smaller, non-amyloid structures that were non-toxic as determined by the lack of caspase 3 activation in a neuroblastoma cell line. 21998304 2011
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 AlteredExpression disease BEFREE These data demonstrate that TNF-α promotes FasL expression through NFAT activation in neuroblastoma cells and this event leads to increased apoptosis through independent caspase-3 activation. 21298033 2011
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE Furthermore, the effects of Aβ and TD/GH on LDH release, apoptosis and its relevant gene expression, involving bcl-2 and bax/caspase-3, were observed in a human neuroblastoma cell line (SH-SY5Y). 20821386 2010
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE The objective of this study is to define apoptosis and necrosis in an in vitro model system of SH-SY5Y cells, and to investigate appropriate defense mechanisms with caspase-3 small interference RNA (siRNA) and necrostatin-1 (Nec-1). 20487627 2010
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE Our recent study showed that xanthoangelol, a major chalcone constituent of the stem exudates of Angelica keiskei, induced caspase-3-dependent apoptosis in neuroblastoma cells. 18379052 2008
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 AlteredExpression disease BEFREE Neuroblastoma and brain tumor cell lines are particularly sensitive to neocarzinostatin; the sensitivity of brain tumor lines to neocarzinostatin is enhanced by transfection with an expression construct for Bcl-2 and is proportional in transfected cells to the product of the relative contents of Bcl-2 and caspase-3 (r (2) = 0.7). 18338171 2008
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE Stable expression of a constitutively active mutant of Gas (GalphasQL) protected gamma ray-induced apoptosis which was assessed by analysis of the cleavages of PARP, caspase-9, and caspase-3 and cytochrome C release in SH-SY5Y human neuroblastoma cells. 18059134 2007
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE In contrast to the usual response typically observed in the majority of cell types, P2X(7) in vitro stimulation did not induce caspase-3 activation or apoptosis of neuroblastoma cells but rather supported their proliferation. 16424024 2006
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.100 Biomarker disease BEFREE Apoptosis but not necrosis was detected at various stages (early: annexin-V; effector: caspase-3) after 24-48 h of incubation with GA, GC, or 3-OH-GA in OLN-93 but not in neuroblastoma or microglia cells. 15774829 2005