Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma. | 31109923 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Derazantinib (ARQ 087) in advanced or inoperable FGFR2 gene fusion-positive intrahepatic cholangiocarcinoma. | 30420614 | 2019 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Low-level clonal FGFR2 amplification defines a unique molecular subtype of intrahepatic cholangiocarcinoma in a Chinese population. | 29514108 | 2018 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Analyses of genetic alterations have identified those that might be targeted therapeutically, such as fusions in the FGFR2 gene and mutations in genes encoding isocitrate dehydrogenases (in approximately 60% of iCCAs) or amplifications at 11q13 and 6p21 (in approximately 15% of HCCs). | 28043904 | 2017 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Recent genomic analysis of cholangiocarcinoma has revealed the presence of fibroblast growth factor receptor 2 (FGFR2) fusion proteins in up to 13% of intrahepatic cholangiocarcinoma (iCCA). | 27216979 | 2016 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Screening of a cohort of 107 iCCA patients reveals that FGFR2 fusions represent the most recurrent targetable alteration (45%, 17/107), while they are rarely present in other primary liver tumours (0/100 of hepatocellular carcinoma (HCC); 1/21 of mixed iCCA-HCC). | 25608663 | 2015 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | FGFR2 fusions and ERRFI mutations may represent novel targets in sporadic intrahepatic cholangiocarcinoma and trials should be characterized in larger cohorts of patients with these aberrations. | 24550739 | 2014 | ||||
|
0.080 | Biomarker | disease | BEFREE | Fibroblast growth factor receptor 2 translocations in intrahepatic cholangiocarcinoma. | 24837095 | 2014 |