Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 AlteredExpression disease BEFREE In fact, C. trachomatis infection in PBMCs failed to induce IFN-γ levels in comparison to the uninfected culture. 30832593 2019
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 Biomarker disease BEFREE Natural infection induces partial immunity to Chlamydia trachomatis Identification of chlamydial antigens that induce interferon γ (IFN-) secretion by T cells from immune women could advance vaccine development. 27738051 2016
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 Biomarker disease BEFREE We used two in vitro models (treatment with IFN-γ or direct limitation of tryptophan), to study the effects of direct rescue by the addition of exogenous indole, or by the addition of culture supernatant from indole-positive versus indole-negative Prevotella strains, on the growth and infectivity of C. trachomatis. 27914477 2016
Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
0.100 Biomarker disease BEFREE The Hsp60 gene was detected in 57 % of the women infected with C. trachomatis. 26944507 2016
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 AlteredExpression disease BEFREE CD4(+) and CD8(+) T cells from subjects grouped into disease-specific cohorts were screened using a C. trachomatis proteomic library to identify the antigen specificities of recall T cell responses after natural exposure by measuring interferon gamma (IFN-γ) levels. 26446421 2015
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 GeneticVariation disease BEFREE Possession of the T allele at position +874 in the gene coding for interferon gamma is associated with a reduced likelihood of a C. trachomatis cervical infection. 25505046 2015
Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
0.100 Biomarker disease BEFREE To identify Chlamydia trachomatis antigens that can be used to differentially diagnose tubal factor infertility in comparison with previously reported heat shock protein 60. 21742324 2011
Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
0.100 Biomarker disease BEFREE C trachomatis-specific immune responses were measured using lymphocyte proliferation (LP) induced by C trachomatis E and F strains and chlamydial heat shock protein 60 antigens. 21215285 2011
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 Biomarker disease BEFREE Our data suggest that interleukin-10 and interferon-γ regulate C trachomatis-specific immune responses in humans and that genetic variation in the expression of their coding genes explains interindividual variation in host immune responses to C trachomatis infection. 21215285 2011
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 Biomarker disease BEFREE This study shows that IFN-γ effector functions on intracellular C. trachomatis depend on the environmental oxygen supply, which could explain inadequate bacterial clearance and subsequent chronic infections eventually occurring in the UGT of women. 20974954 2010
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 AlteredExpression disease BEFREE We found that the Th1 subset dominated the UGT, as IFN-γ and T-bet mRNA expression were high, while GATA-3 was low following genital infection with C. trachomatis serovar D. By contrast, IL-10 and GATA-3 mRNA dominated the LGT, suggesting the presence of Th2 cells. 21079691 2010
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 Biomarker disease BEFREE Accordingly, IFNgamma-mediated suppressing effects on Chlamydia trachomatis (CT) infection were reduced or even abolished in the presence of FeSO(4). 19306922 2009
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 AlteredExpression disease BEFREE With use of the IFN-gamma enzyme-linked immunosorbent spot assay, we investigated immune responses to Chlamydia elementary body (EB) and 3 genotypically variant heat shock protein 60 (CHSP60) antigens using peripheral blood mononuclear cells and endometrial mononuclear cells obtained from a female sex worker cohort with high levels of exposure to C. trachomatis. 19419333 2009
Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
0.100 AlteredExpression disease BEFREE With use of the IFN-gamma enzyme-linked immunosorbent spot assay, we investigated immune responses to Chlamydia elementary body (EB) and 3 genotypically variant heat shock protein 60 (CHSP60) antigens using peripheral blood mononuclear cells and endometrial mononuclear cells obtained from a female sex worker cohort with high levels of exposure to C. trachomatis. 19419333 2009
Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
0.100 Biomarker disease BEFREE Evidence of past infection with C. trachomatis was demonstrated in 96 cases by use of a combined test for humoral and cell-mediated immune responses to chlamydial elementary bodies (EBs) and chlamydial heat-shock protein 60 antigens. 19358670 2009
Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
0.100 GeneticVariation disease BEFREE A comparative analysis of the products of GROEL-1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible autoimmune response. 19207939 2009
Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
0.100 Biomarker disease BEFREE Real-time (LightCycler) PCR for relative C. trachomatis quantification following DNA extraction was performed using primers (Hsp 60) for the 60 kDa heat-shock protein hsp60 gene. 15787650 2005
Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
0.100 AlteredExpression disease BEFREE Differential expression of three Chlamydia trachomatis hsp60-encoding genes in active vs. persistent infections. 14643638 2004
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 GeneticVariation disease BEFREE We measured and compared previously significant human leukocyte antigen (HLA) class II DQ alleles, their linked DRB genes, and polymorphisms in selected cytokine genes (tumor necrosis factor alpha-308 promoter; transforming growth factor beta1-10 and -25 codons; interleukin 10-1082, -819, and -592 promoters; interleukin 6-174 promoter; and interferon gamma+874 codon 1) among Kenyan women with confirmed tubal infertility with and without C trachomatis microimmunofluorescence antibody. 12636945 2003
Entrez Id: 5045
Gene Symbol: FURIN
FURIN
0.100 Biomarker disease BEFREE These data have substantiated, using a large multicenter sample and a patient standard, that LCR and PCR tests performed on endocervical swabs and urine are superior to PACE 2 tests for screening C. trachomatis infections in women. 12354877 2002
Entrez Id: 3329
Gene Symbol: HSPD1
HSPD1
0.100 Biomarker disease BEFREE Association of Chlamydia trachomatis heat-shock protein 60 antibody and HLA class II DQ alleles. 10353888 1999
Entrez Id: 5045
Gene Symbol: FURIN
FURIN
0.100 Biomarker disease BEFREE Prospective comparison of the Gen-probe PACE 2 assay and the Abbott ligase chain reaction for the direct detection of Chlamydia trachomatis in a low prevalence population. 10229549 1999
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 Biomarker disease BEFREE In the present study, we surprisingly observed that C. trachomatis mouse pneumonitis MoPn-infected IFN-gamma gene knockout (KO) mice mounted strong DTH responses following foopad challenge with inactivated organisms. 10556835 1999
Entrez Id: 5045
Gene Symbol: FURIN
FURIN
0.100 Biomarker disease BEFREE To validate a protocol for HC II C. trachomatis and N. gonorrhoeae testing of specimens collected for the GenProbe PACE 2 System. 10333286 1999
Entrez Id: 5045
Gene Symbol: FURIN
FURIN
0.100 GeneticVariation disease BEFREE PCR detected C. trachomatis at 11 twofold dilutions greater than PACE 2 and equivalent to detection of single elementary body by Syva Direct Specimen Test. 9587179 1998