Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE LRRK2 Gly2385Arg polymorphism, cigarette smoking, and risk of sporadic Parkinson's disease: a case-control study in Japan. 20673920 2010
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE Gain-of-function mutations in leucine-rich repeat kinase 2 (LRRK2) cause familial as well as sporadic Parkinson's disease characterized by age-dependent degeneration of dopaminergic neurons. 20671708 2010
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease. 18337586 2008
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE To investigate mechanisms by which LRRK2 might cause PD. 22204929 2012
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE The R1628P and G2385R polymorphisms of the LRRK2 gene have been identified as exclusively associated with PD in Asian populations, particularly in Han Chinese population. 25511328 2015
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE The LRRK2 G2019S mutation is the most frequent known cause of familial and sporadic Parkinson's disease. 19945904 2010
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Human genetics studies have linked LRRK2 as a major genetic contributor to familial and sporadic Parkinson's disease (PD), a neurodegenerative movement disorder that inflicts millions worldwide. 30635421 2019
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE The disposition of Aβ and tau is likely important in both LRRK2-related and sporadic PD, even during early phases of the disease. 22170881 2012
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE The "common" LRRK2 G2019S kinase domain substitution has been reported to account for approximately 5% of familial and 1% of sporadic Parkinson disease. 16966501 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE In this review, we focus on the recent advances on the role of Rab GTPases in the biology of two main proteins involved in Parkinson's disease: LRRK2 and α-synuclein, given that mutations in their genes (LRRK2 and SNCA) cause familial and sporadic Parkinson's disease. 31054512 2019
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE Our results suggest that mutant (G2019S) LRRK2 activates MKK4-JNK-c-Jun pathway in the SN and causes the resulting degeneration of SNpc dopaminergic neurons in PD transgenic mice. 22539006 2012
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE The G2019S LRRK2 mutation is uncommon amongst Greek patients with sporadic Parkinson's disease. 17880562 2007
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE These findings show that the cerebral cortex in familial PD linked with G2019S LRRK2 is affected in a similar way than that seen in sporadic PD without cognitive impairment. 20232069 2010
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Together, these findings suggest that downregulation of miR-205 may contribute to the potential pathogenic elevation of LRRK2 protein in the brains of patients with sporadic PD, while overexpression of miR-205 may provide an applicable therapeutic strategy to suppress the abnormal upregulation of LRRK2 protein in PD. 23125283 2013
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Olfactory dysfunction in sporadic Parkinson's Disease and LRRK2 carriers. 23937295 2014
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE Comprehensive evaluation of common genetic variation within LRRK2 reveals evidence for association with sporadic Parkinson's disease. 16269443 2005
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE Patients with LRRK2 mutations had typical clinical features of PD. 17115391 2007
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE On the other hand, the constitutive mutant of LRRK2(R1441G), known to cause PD, leads to down-regulation of the same pathway. 23600457 2013
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE Common variants of LRRK2 are not associated with sporadic Parkinson's disease. 16254973 2005
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE As such, delineating the functional pathways for LRRK2 and mechanisms by which PD-linked variants contribute to age-related neurodegeneration could result in pharmaceutically tractable therapies. 24225420 2014
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE In summary, our footprint-free LRRK2-G2019S isogenic cell lines allow standardized, genetic background independent, in vitro PD modeling and provide new insights into the role of LRRK2-G2019S and S129P-αS in the pathogenesis of PD. 28826027 2017
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Recent research has focused on neuroinvasive influenza A viruses (IAV), whereas a genetic link between sPD and tuberculosis has arisen in LRRK2 - dependent maturation of the phagosome. 31765844 2020
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Our study indicates that this LRRK2 p.2385G>R substitution contributes to the development of PD in ethnic Han-Chinese population, which may play important implications for future study on molecular genetics and pathogenesis of PD. 18201193 2008
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE Based on these findings, Latourelle and colleagues show that the penetrance of the most common LRRK2 mutation is higher in patients with familial compared with sporadic Parkinson's disease and identified a substantial number of affected relatives of mutation carriers not presenting with a LRRK2 mutation themselves. 18986509 2008
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE To study recurrent LRRK2 mutations in a large sample of patients from Italy, including early (<50 years) and late onset familial and sporadic Parkinson's disease. 16272257 2005