Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Recent research has focused on neuroinvasive influenza A viruses (IAV), whereas a genetic link between sPD and tuberculosis has arisen in LRRK2 - dependent maturation of the phagosome. 31765844 2020
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Human genetics studies have linked LRRK2 as a major genetic contributor to familial and sporadic Parkinson's disease (PD), a neurodegenerative movement disorder that inflicts millions worldwide. 30635421 2019
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE In this review, we focus on the recent advances on the role of Rab GTPases in the biology of two main proteins involved in Parkinson's disease: LRRK2 and α-synuclein, given that mutations in their genes (LRRK2 and SNCA) cause familial and sporadic Parkinson's disease. 31054512 2019
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE We demonstrate that these organoids can recapitulate the 3D pathological hallmarks observed in patients with LRRK2-associated sporadic Parkinson's disease. 30799274 2019
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE LRRK2 links genetic and sporadic Parkinson's disease. 30837320 2019
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Leucine-rich repeat kinase 2 (LRRK2) is a molecule associated with familial and sporadic Parkinson's disease. 31555076 2019
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE Mutations in LRRK2 cause autosomal dominant and sporadic Parkinson's disease but the mechanisms involved in LRRK2 toxicity in PD are yet to be fully understood. 31626293 2019
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene account for most common causes of familial and sporadic Parkinson's disease (PD) and are one of the strongest genetic risk factors in sporadic PD. 29894679 2019
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE Mutations in leucine-rich repeat kinase 2 gene (<i>LRRK2</i>) are associated with familial and sporadic Parkinson's disease (PD). 29541021 2018
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Our study suggests that Rab GTPases might mediate LRRK2 toxicity in the progression of PD. 29439717 2018
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE LRRK2 p.G2385R is an Asian specific genetic risk factor for sporadic Parkinson's disease. 29414410 2018
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Taken together, a LRRK2-WAVE2 pathway, which modulates the phagocytic response in mice and human leukocytes, may define an important role for altered immune function in PD. 29760073 2018
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Consequently, there is much interest in understanding LRRK2 and its role in PD pathogenesis. 30194047 2018
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE In summary, our footprint-free LRRK2-G2019S isogenic cell lines allow standardized, genetic background independent, in vitro PD modeling and provide new insights into the role of LRRK2-G2019S and S129P-αS in the pathogenesis of PD. 28826027 2017
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 PosttranslationalModification disease BEFREE Thus, APP is a substrate of LRRK2, and its phosphorylation promotes AICD function and neurotoxicity in PD. 28720718 2017
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE Using PET, we assessed whether dopaminergic and serotonin transporter changes are similar in LRRK2 mutation carriers with Parkinson's disease and individuals with sporadic Parkinson's disease, and whether LRRK2 mutation carriers without motor symptoms show PET changes. 28336296 2017
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE The identification of Rab10 phosphorylated at Thr73 as a LRRK2 inhibition marker in human PBMCs strongly support inclusion of assays quantifying Rab10-pThr73 levels in upcoming clinical trials evaluating LRRK2 kinase inhibition as a disease-modifying treatment principle in PD. 28860483 2017
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Leucine-rich repeat kinase 2 gene (LRRK2) was recognized associated with both familial and sporadic Parkinson Disease (PD). 28131193 2017
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE Portugal has been identified as one of the countries with a high prevalence of LRRK2-G2019S, considered to be the most frequent known cause of familial and sporadic Parkinson's disease (PD). 28251720 2017
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Up to date, the role of LRRK2 in PD onset and progression remains largely unknown. 28582422 2017
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE In contrast, LRRK1, the closest homologue to LRRK2, does not play any role in PD. 28819229 2017
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE In North African populations, G2019S mutation in LRRK2 gene, encoding for the leucine-rich repeat kinase 2, is the most prevalent mutation linked to familial and sporadic Parkinson's disease (PD). 28683740 2017
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Leucine-rich repeat kinase 2 (LRRK2) is a recently discovered molecule associated with familial and sporadic Parkinson's disease. 28168579 2017
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Leucine-rich repeat kinase 2 (LRRK2) has been linked to familial and sporadic Parkinson's disease. 28041945 2017
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE To evaluate whether LRRK2 inhibitors are effective therapies for PD, it is crucial to know whether LRRK2 inhibitors will affect dopaminergic (DAergic) neurotransmission. 27943591 2017