Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.100 Biomarker disease BEFREE Alpha-synuclein accumulates in the brains of sporadic Parkinson's disease patients as a major component of Lewy bodies, and mutations in alpha-synuclein are associated with familial forms of Parkinson's disease. 11440819 2001
Entrez Id: 10
Gene Symbol: NAT2
NAT2 		0.020 GeneticVariation disease BEFREE N-acetyltransferase 2 polymorphism in sporadic Parkinson's disease in a Polish population. 11936704 2002
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.100 Biomarker disease BEFREE Alpha-synuclein was implicated in Parkinson's disease when missense mutations in the alpha-synuclein gene were found in autosomal dominant Parkinson's disease and alpha-synuclein was shown to be a major constituent of protein aggregates in sporadic Parkinson's disease and other synucleinopathies. 14572463 2003
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.100 AlteredExpression disease BEFREE Alpha-synuclein mRNA expression in sporadic Parkinson's disease. 15719423 2005
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.050 GeneticVariation disease BEFREE Apolipoprotein E epsilon4 allele in familial and sporadic Parkinson's disease. 16904828 2006
Entrez Id: 4929
Gene Symbol: NR4A2
NR4A2 		0.020 GeneticVariation disease BEFREE NR4A2 genetic variation in sporadic Parkinson's disease: a genewide approach. 16977628 2006
Entrez Id: 627
Gene Symbol: BDNF
BDNF 		0.030 GeneticVariation disease BEFREE BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups. 17229524 2007
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2 		0.100 GeneticVariation disease BEFREE LRRK2 low-penetrance mutations (Gly2019Ser) and risk alleles (Gly2385Arg)-linking familial and sporadic Parkinson's disease. 17440812 2007
Entrez Id: 3552
Gene Symbol: IL1A
IL1A 		0.010 GeneticVariation disease BEFREE Interleukin-1 alpha polymorphism has influence on late-onset sporadic Parkinson's disease in Taiwan. 17458495 2007
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.100 Biomarker disease BEFREE SNCA multiplication is present in sporadic Parkinson disease (PD) and needs to be screened. 17625105 2008
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2 		0.100 GeneticVariation disease BEFREE Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease. 18337586 2008
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2 		0.100 GeneticVariation disease BEFREE LRRK2 G2019S and R1441C mutations associated with PD were not an uncommon mutation in a Sardinian population, especially in sporadic PD patients. 18805725 2009
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2 		0.100 GeneticVariation disease BEFREE LRRK2 P755L variant in sporadic Parkinson's disease. 18923807 2008
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2 		0.100 GeneticVariation disease BEFREE LRRK2 Gly2385Arg polymorphism, cigarette smoking, and risk of sporadic Parkinson's disease: a case-control study in Japan. 20673920 2010
Entrez Id: 2629
Gene Symbol: GBA
GBA 		0.090 GeneticVariation disease BEFREE β-Glucocerebrosidase gene mutations in two cohorts of Greek patients with sporadic Parkinson's disease. 21745757 2012
Entrez Id: 2630
Gene Symbol: GBAP1
GBAP1 		0.010 GeneticVariation disease BEFREE β-Glucocerebrosidase gene mutations in two cohorts of Greek patients with sporadic Parkinson's disease. 21745757 2012
Entrez Id: 2551
Gene Symbol: GABPA
GABPA 		0.010 Biomarker disease BEFREE NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease. 21747966 2011
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2 		0.010 Biomarker disease BEFREE NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease. 21747966 2011
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1 		0.010 GeneticVariation disease BEFREE HLA-DRB1 alleles are associated with the susceptibility to sporadic Parkinson's disease in Chinese Han population. 23139797 2012
Entrez Id: 56922
Gene Symbol: MCCC1
MCCC1 		0.020 GeneticVariation disease BEFREE MCCC1/LAMP3 reduces risk of sporadic Parkinson's disease in Han Chinese. 23496138 2013
Entrez Id: 6622
Gene Symbol: SNCA
SNCA 		0.100 GeneticVariation disease BEFREE SNCA rs356219 variant increases risk of sporadic Parkinson's disease in ethnic Chinese. 23737253 2013
Entrez Id: 26281
Gene Symbol: FGF20
FGF20 		0.010 GeneticVariation disease BEFREE Fibroblast growth factor 20 polymorphism in sporadic Parkinson's disease in Northern Han Chinese. 23938014 2013
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		0.020 GeneticVariation disease BEFREE MTHFR C677T variant reduces risk of sporadic Parkinson's disease in ethnic Chinese. 24628244 2014
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.050 Biomarker disease BEFREE APOE ε4 is considered a marker for poor prognosis in various diseases, but APOE ε2 rather than APOE ε4 has been associated with cerebral amyloid angiopathy-related bleeding and sporadic Parkinson's disease. 26646927 2015
Entrez Id: 100359403
Gene Symbol: PARK16
PARK16 		0.030 GeneticVariation disease BEFREE PARK16 polymorphisms, interaction with smoking, and sporadic Parkinson's disease in Japan. 26944116 2016