Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.010 GeneticVariation disease BEFREE Novel and functional ABCB1 gene variant in sporadic Parkinson's disease. 24572589 2014
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.010 GeneticVariation disease BEFREE We also failed to observe any significant association with the occurrence of L-dopa-induced adverse effects in long-term treated PD patients, thereby excluding the presence of an association between ACE I/D genotypes and the genetic susceptibility to PD and the development of adverse effect of chronic L-dopa therapy. 18805557 2009
Entrez Id: 130013
Gene Symbol: ACMSD
ACMSD
0.010 GeneticVariation disease BEFREE A Novel p.Glu298Lys Mutation in the ACMSD Gene in Sporadic Parkinson's Disease. 28671144 2017
Entrez Id: 177
Gene Symbol: AGER
AGER
0.010 GeneticVariation disease BEFREE Association of RAGE gene polymorphisms with sporadic Parkinson's disease in Chinese Han population. 24304868 2014
Entrez Id: 196
Gene Symbol: AHR
AHR
0.010 Biomarker disease BEFREE These results suggest that treatments designed to induce PRKN expression through the use of nontoxic AhR agonist ligands may be novel strategies to prevent and delay PD. 31404530 2019
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.010 GeneticVariation disease BEFREE Association of AKT1 gene polymorphisms with sporadic Parkinson's disease in Chinese Han population. 27353512 2016
Entrez Id: 301
Gene Symbol: ANXA1
ANXA1
0.010 GeneticVariation disease BEFREE We revealed that among the 22 potential loci implicated, PRDM2/KIAA1026 (kgp8090149), TSG1/MANEA (kgp154172), PDE10A (kgp8130520), MDGA2 (rs9323124), ATPBD4/LOC100288892 (kgp11333367), ZFP64/TSHZ2 (kgp4156164), PAQR3/ARD1B (kgp9482779), FLJ23172/FNDC3B (kgp760898), C18orf1 (kgp348599), FLJ43860/NCRNA00051 (kgp4105983), CYP1B1/C2orf58 (kgp11353523), WNT9A/LOC728728 (rs849898), ANXA1/LOC100130911 (rs10746953), FLJ35379/LOC100132423 (kgp9550589), PLEKHN1 (kgp7172368), DMRT2/SMARCA2 (kgp10769919), ZNF396/INO80C (rs1362858), C3orf67/LOC339902 (rs6783485), LOC285194/IGSF11 (rs1879553), FGF10/MRPS30 (rs13153459), BARX1/PTPDC1 (kgp6542803), and COL5 A2 (rs11186), the peak significance was at the kgp4105983 of FLJ43860 gene in chromosome 8, the first top strongest associated locus with sPD was PRDM2 (kgp8090149) in chromosome 1, and the 24 pathways including 100 significantly associated genes were strongly associated with sPD from HPCM. 26227905 2016
Entrez Id: 328
Gene Symbol: APEX1
APEX1
0.010 GeneticVariation disease BEFREE Association study of sporadic Parkinson's disease genetic risk factors in patients from Russia by APEX technology. 16876316 2006
Entrez Id: 348
Gene Symbol: APOE
APOE
0.050 GeneticVariation disease BEFREE Apolipoprotein E epsilon4 allele in familial and sporadic Parkinson's disease. 16904828 2006
Entrez Id: 348
Gene Symbol: APOE
APOE
0.050 Biomarker disease BEFREE APOE ε4 is considered a marker for poor prognosis in various diseases, but APOE ε2 rather than APOE ε4 has been associated with cerebral amyloid angiopathy-related bleeding and sporadic Parkinson's disease. 26646927 2015
Entrez Id: 348
Gene Symbol: APOE
APOE
0.050 GeneticVariation disease BEFREE In contrast to reports in oriental populations, our results do not support a major role of APOE, PARKIN and COMT polymorphisms in PD susceptibility in the Finnish population. 12270650 2002
Entrez Id: 348
Gene Symbol: APOE
APOE
0.050 GeneticVariation disease BEFREE The frequency of the APOE allele epsilon4 was similar in patients with Parkinson's disease and controls, but the APOE allele epsilon2, thought to be protective for dementia, was significantly more frequent in patients with sporadic Parkinson's disease than in controls. 9328263 1997
Entrez Id: 348
Gene Symbol: APOE
APOE
0.050 GeneticVariation disease BEFREE A recent study showed significant association of sporadic Parkinson's disease with a polymorphism within the alpha-synuclein gene and closely linked DNA markers on chromosome 4q and the APOE epsilon4 allele. 11357958 2001
Entrez Id: 351
Gene Symbol: APP
APP
0.010 Biomarker disease BEFREE Thus, APP is a substrate of LRRK2, and its phosphorylation promotes AICD function and neurotoxicity in PD. 28720718 2017
Entrez Id: 9140
Gene Symbol: ATG12
ATG12
0.010 GeneticVariation disease BEFREE Novel and functional ATG12 gene variants in sporadic Parkinson's disease. 28229934 2017
Entrez Id: 55054
Gene Symbol: ATG16L1
ATG16L1
0.010 PosttranslationalModification disease BEFREE Genetic analysis of the ATG16L1 gene promoter in sporadic Parkinson's disease. 28279708 2017
Entrez Id: 9474
Gene Symbol: ATG5
ATG5
0.010 PosttranslationalModification disease BEFREE A novel and functional variant within the ATG5 gene promoter in sporadic Parkinson's disease. 23384565 2013
Entrez Id: 10533
Gene Symbol: ATG7
ATG7
0.010 PosttranslationalModification disease BEFREE Genetic analysis of the ATG7 gene promoter in sporadic Parkinson's disease. 23295909 2013
Entrez Id: 56033
Gene Symbol: BARX1
BARX1
0.010 GeneticVariation disease BEFREE We revealed that among the 22 potential loci implicated, PRDM2/KIAA1026 (kgp8090149), TSG1/MANEA (kgp154172), PDE10A (kgp8130520), MDGA2 (rs9323124), ATPBD4/LOC100288892 (kgp11333367), ZFP64/TSHZ2 (kgp4156164), PAQR3/ARD1B (kgp9482779), FLJ23172/FNDC3B (kgp760898), C18orf1 (kgp348599), FLJ43860/NCRNA00051 (kgp4105983), CYP1B1/C2orf58 (kgp11353523), WNT9A/LOC728728 (rs849898), ANXA1/LOC100130911 (rs10746953), FLJ35379/LOC100132423 (kgp9550589), PLEKHN1 (kgp7172368), DMRT2/SMARCA2 (kgp10769919), ZNF396/INO80C (rs1362858), C3orf67/LOC339902 (rs6783485), LOC285194/IGSF11 (rs1879553), FGF10/MRPS30 (rs13153459), BARX1/PTPDC1 (kgp6542803), and COL5 A2 (rs11186), the peak significance was at the kgp4105983 of FLJ43860 gene in chromosome 8, the first top strongest associated locus with sPD was PRDM2 (kgp8090149) in chromosome 1, and the 24 pathways including 100 significantly associated genes were strongly associated with sPD from HPCM. 26227905 2016
Entrez Id: 10295
Gene Symbol: BCKDK
BCKDK
0.010 Biomarker disease BEFREE Association of three candidate genetic variants in ACMSD/TMEM163, GPNMB and BCKDK /STX1B with sporadic Parkinson's disease in Han Chinese. 30880162 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.030 Biomarker disease BEFREE Early loss of NA activity and anterograde neurotrophin support may contribute to degeneration of vulnerable neurons in PD and other neurodegenerative disorders. 31734438 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.030 Biomarker disease BEFREE Furthermore, added knockout of the dopamine-metabolizing enzyme aldehyde dehydrogenase, found almost absent in sporadic PD SN pars compacta, exacerbated the vulnerability of SKP1A-silenced neurons to MPP(+) and neurotrophin deprivation. 20173338 2010
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.030 GeneticVariation disease BEFREE BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups. 17229524 2007
Entrez Id: 683
Gene Symbol: BST1
BST1
0.010 GeneticVariation disease BEFREE Lack of association between BST1 polymorphisms and sporadic Parkinson's disease in a Japanese population. 23026536 2012
Entrez Id: 200844
Gene Symbol: C3orf67
C3orf67
0.010 GeneticVariation disease BEFREE We revealed that among the 22 potential loci implicated, PRDM2/KIAA1026 (kgp8090149), TSG1/MANEA (kgp154172), PDE10A (kgp8130520), MDGA2 (rs9323124), ATPBD4/LOC100288892 (kgp11333367), ZFP64/TSHZ2 (kgp4156164), PAQR3/ARD1B (kgp9482779), FLJ23172/FNDC3B (kgp760898), C18orf1 (kgp348599), FLJ43860/NCRNA00051 (kgp4105983), CYP1B1/C2orf58 (kgp11353523), WNT9A/LOC728728 (rs849898), ANXA1/LOC100130911 (rs10746953), FLJ35379/LOC100132423 (kgp9550589), PLEKHN1 (kgp7172368), DMRT2/SMARCA2 (kgp10769919), ZNF396/INO80C (rs1362858), C3orf67/LOC339902 (rs6783485), LOC285194/IGSF11 (rs1879553), FGF10/MRPS30 (rs13153459), BARX1/PTPDC1 (kgp6542803), and COL5 A2 (rs11186), the peak significance was at the kgp4105983 of FLJ43860 gene in chromosome 8, the first top strongest associated locus with sPD was PRDM2 (kgp8090149) in chromosome 1, and the 24 pathways including 100 significantly associated genes were strongly associated with sPD from HPCM. 26227905 2016