Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE Hypomethylation of SNCA in blood of patients with sporadic Parkinson's disease. 24326201 2014
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE We failed to demonstrate an association of any NACP-REP1 allele with PD. 14583385 2003
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE Although the etiology for sporadic Parkinson's disease is unknown, information gleaned from both familial forms of the disease and animal models places misfolded alpha-synuclein at the forefront. 18840530 2009
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE However, it is unknown how alpha-synuclein is involved in the pathogenesis of nigral degeneration in PD. 12059041 2002
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 AlteredExpression disease BEFREE Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients. 16795004 2006
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE Genetic Variants in SNCA and the Risk of Sporadic Parkinson's Disease and Clinical Outcomes: A Review. 28781905 2017
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE In summary, our footprint-free LRRK2-G2019S isogenic cell lines allow standardized, genetic background independent, in vitro PD modeling and provide new insights into the role of LRRK2-G2019S and S129P-αS in the pathogenesis of PD. 28826027 2017
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE Gene multiplications or point mutations in alpha (α)-synuclein are associated with familial and sporadic Parkinson's disease (PD). 25497688 2015
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE Alpha-synuclein was implicated in Parkinson's disease when missense mutations in the alpha-synuclein gene were found in autosomal dominant Parkinson's disease and alpha-synuclein was shown to be a major constituent of protein aggregates in sporadic Parkinson's disease and other synucleinopathies. 14572463 2003
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE No mutations were found in any of the patients, suggesting that a mutation at the coding region of the alpha-synuclein gene is unlikely to be responsible for nigrostriatal degeneration in typical sporadic Parkinson's disease. 9566408 1998
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE Further, the "protective" genotype 259/259 of the PD-associated promoter repeat NACP-Rep1 is associated with lower protein levels in blood than genotypes 261/261, 259/261, and 259/263. 18162487 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE We found that the levels of these interactions were aberrantly increased by the I93M mutation, and that expression of I93M UCH-L1 in cells induced the CMA inhibition-associated increase in the amount of alpha-synuclein, a risk factor for PD. 18635949 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE Role of Sporadic Parkinson Disease Associated Mutations A18T and A29S in Enhanced α-Synuclein Fibrillation and Cytotoxicity. 28841377 2018
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE The polymorphic mixed sequence repeat (NACP-Rep1) in the promoter region of SNCA has been previously examined as a potential susceptibility factor for PD with conflicting results. 15670652 2005
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE Thus, the association of different NACP-Rep1 alleles with PD may be a consequence of polymorphic differences in transcriptional regulation of SNCA. 15672325 2005
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE The discovery of alpha-synuclein mutations in families with autosomal dominant Parkinson's disease sheds light on its role in sporadic Parkinson's disease. 11433638 2001
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE We screened SNCA exon 3 in 988 patients without SNCA multiplications (430 with autosomal dominant PD and 558 with sporadic PD). 28666710 2017
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE However, the mechanisms by which subtle variations in the expression of wild-type SNCA and MAPT influence risk for PD and the underlying cellular events that effect neurotoxicity remain unclear. 24430504 2014
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE Furthermore, to enhance the pathological properties of α-synuclein, we inserted into SNCA an A53T mutation, two single-nucleotide polymorphisms identified in a genome-wide association study in Parkinson's disease and a Rep1 polymorphism, all of which are causal of familial Parkinson's disease or increase the risk of sporadic Parkinson's disease. 31816026 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE No mutation of G209A in the alpha-synuclein gene in sporadic Parkinson's disease among Taiwan Chinese. 10023110 1999
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE Increased availability of the fibrillogenic protein substrates of the pathological aggregates that define several neurodegenerative proteopathies, eg α-synuclein in PD, β-amyloid in AD and tau in the tauopathies, contributes to causation and risk in the familial and sporadic forms of these disorders, respectively. 20704554 2010
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE Because sequence variants in the SNCA gene are not only associated with autosomal dominantly inherited PD and increased susceptibility for sporadic PD but also have been found to modify the phenotype such as age at onset in both sporadic and various monogenic forms of PD, this gene serves as an outstanding target for further research on PD pathogenesis, which in return might provide potential therapeutic options.© 2013 Movement Disorder Society. 23674386 2013
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE Alpha-synuclein accumulates in the brains of sporadic Parkinson's disease patients as a major component of Lewy bodies, and mutations in alpha-synuclein are associated with familial forms of Parkinson's disease. 11440819 2001
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE SNCA rs356182 variant increases risk of sporadic Parkinson's disease in ethnic Chinese. 27538639 2016
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE A recent study showed significant association of sporadic Parkinson's disease with a polymorphism within the alpha-synuclein gene and closely linked DNA markers on chromosome 4q and the APOE epsilon4 allele. 11357958 2001