Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.070 GeneticVariation disease BEFREE Although it remains difficult to conclusively demonstrate the pathogenicity of heterozygous mutations, the results of this study and the previously reported subclinical nigrostriatal dysfunction in carriers of heterozygous PINK1 mutations suggest the possibility that these heterozygous mutations are a significant risk factor in the development of later onset PD. 16969854 2006
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.070 Biomarker disease BEFREE PTEN induced putative kinase 1 (PINK1), also known as PARK6, is causally linked to familial Parkinsonism, and heterozygous loss of PINK1 is a risk factor for sporadic Parkinson's disease. 29843233 2018
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.070 AlteredExpression disease BEFREE We also show that PINK1 mRNA expression is similar in nigral neurons from neurologically normal controls and sporadic Parkinson's disease cases. 17950257 2007
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.070 Biomarker disease BEFREE We have now tested a candidate interactor protein of PINK1, the mitochondrial translation initiation factor 3 (MTIF3) for involvement in PD pathogenesis. 17267121 2007
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.070 GeneticVariation disease BEFREE We analyzed whether six different genetic variants within and surrounding PINK1 contribute to the risk of sporadic PD in a Finnish case-control series. 16046032 2006
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.070 Biomarker disease BEFREE In addition, we show that PINK1 is detected in a proportion of Lewy bodies in cases of sporadic Parkinson's disease and Parkinson's disease associated with heterozygous mutations in the PINK1 gene, which are clinically and pathologically indistinguishable from the sporadic cases. 16702191 2006
Entrez Id: 65018
Gene Symbol: PINK1
PINK1
0.070 GeneticVariation disease BEFREE However, the identification of recessive pathogenic mutations in the pink1 gene in familial PD cases firmly re-ignited interest in the pathophysiology of mitochondria in PD. 20049715 2009