Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | GeneticVariation | disease | BEFREE | β-Glucocerebrosidase gene mutations in two cohorts of Greek patients with sporadic Parkinson's disease. | 21745757 | 2012 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | About one-third of patients with sporadic Parkinson disease (PD) and more than 40% of patients with familial PD of Ashkenazi Jewish descent likely carry the G2019S mutation in the LRRK2 gene, a mutation in the glucocerebrosidase (GBA) gene, or both. | 25347348 | 2014 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Association between GBA L444P mutation and sporadic Parkinson's disease from Mainland China. | 20004703 | 2010 | ||||
|
0.090 | Biomarker | disease | BEFREE | Characterization of Brain Lysosomal Activities in GBA-Related and Sporadic Parkinson's Disease and Dementia with Lewy Bodies. | 29948939 | 2019 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Haploinsufficiency of the GBA gene, leading to a reduction in glucocerebrosidase (GCase) activity, is one of the most common genetic risk factors for PD. | 29735433 | 2018 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Mutations in the LRRK2 and GBA genes are increasingly recognized as frequent determinants of familial and sporadic Parkinson's disease (PD). | 23726462 | 2013 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | Parkin levels were slightly increased only in the PD group without GBA1 mutations and were not significantly modified by ambroxol. | 26094596 | 2015 | ||||
|
0.090 | Biomarker | disease | BEFREE | The characteristic clinical phenotype of GBA1-PD resembles sporadic Parkinson disease, but with an earlier onset and more severe course. | 31188151 | 2019 | ||||
|
0.090 | GeneticVariation | disease | BEFREE | We investigated relationships between Parkinson's disease-specific glucocerebrosidase deficits, glucocerebrosidase-related pathways, and α-synuclein levels in brain tissue from subjects with sporadic Parkinson's disease without GBA1 mutations. | 24477431 | 2014 |