Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE To extend our previous finding in a larger sample and further determine the role of SNCA in the development of PD, we screened a sample of 194 familial PD (FPD), 327 sporadic PD (SPD), and 215 controls with the Rep1 marker and 2 single nucleotide polymorphisms (SNPs) (770 and int4) in the SNCA gene. 17292657 2007
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 AlteredExpression disease BEFREE Converging pieces of evidence suggest that the levels of ASYN expression play a critical role in both familial and sporadic Parkinson's disease. 19476547 2009
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE Small molecules targeting αSyn reverted the degenerative phenotype under both basal and induced stress conditions, indicating a treatment strategy for PD and other synucleinopathies. 28416701 2017
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 AlteredExpression disease BEFREE Alpha-synuclein mRNA expression in sporadic Parkinson's disease. 15719423 2005
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 AlteredExpression disease BEFREE Brain regions with and without a Parkinson's disease-related increase in α-synuclein levels were assessed in autopsy samples from subjects with sporadic Parkinson's disease (n = 19) and age- and post-mortem delay-matched controls (n = 10). 24477431 2014
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE We hypothesize dysregulated expression of wild-type alpha-synuclein results in parkinsonism and may explain the recent association of common SNCA variants in sporadic Parkinson's disease. 18571778 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE Mutation in the alpha-synuclein gene and sporadic Parkinson's disease, Alzheimer's disease, and dementia with lewy bodies. 9743579 1998
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease. 18568448 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE In addition, alpha-synuclein is an abundant component of Lewy bodies in sporadic Parkinson's disease and diffuse Lewy body disease. 10722726 2000
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE An association between common variants in SNCA and risk of sporadic Parkinson's disease has been established through numerous studies. 21800132 2011
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE Patients with the alpha-synuclein mutation were significantly younger (mean 7.6 years), showed the first sign of the disease significantly earlier in life (mean 10.8 years), and had significantly longer duration of the disease compared with patients with sPD. 11309462 2001
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE SNCA rs356219 variant increases risk of sporadic Parkinson's disease in ethnic Chinese. 23737253 2013
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE Dopamine Cytotoxicity on SH-SY5Y Cells: Involvement of α-Synuclein and Relevance in the Neurodegeneration of Sporadic Parkinson's Disease. 30806984 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE The protein alpha-synuclein accumulates in the brain of patients with sporadic Parkinson's disease (PD), and increased gene dosage causes a severe, dominantly inherited form of PD, but we know little about the effects of synuclein that precede degeneration. alpha-Synuclein localizes to the nerve terminal, but the knockout has little if any effect on synaptic transmission. 20152114 2010
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 AlteredExpression disease BEFREE These data indicate that overexpression of alpha-synuclein is sufficient to cause olfactory deficits in mice similar to that observed in patients with PD. 18702696 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE Post mortem studies on familial and sporadic Parkinson's disease patient striatal tissue have shown that nearly 90% of α-synuclein deposited in Lewy-bodies is phosphorylated at serine-129 (pSyn-129) as opposed to only 4% in normal human brain. 27064513 2016
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE Recently, toxic α-synuclein oligomer, which can mediate cell-to-cell propagation is suggested to cause sporadic Parkinson disease. 29892158 2018
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE We provide evidence for functional consequences of PD-associated SNCA gene variants at the 3' region, suggesting that genetic regulation of SNCA splicing plays an important role in the development of the disease. 21046180 2011
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE In this review, we focus on the recent advances on the role of Rab GTPases in the biology of two main proteins involved in Parkinson's disease: LRRK2 and α-synuclein, given that mutations in their genes (LRRK2 and SNCA) cause familial and sporadic Parkinson's disease. 31054512 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE In PARK1-linked PD, mutant alpha-synuclein proteins initiate the disease process as they have increased tendency for self-aggregation. 18426756 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE The role of the alpha-synuclein gene mutation in patients with sporadic Parkinson's disease in the United Kingdom. 9728955 1998
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE α-synuclein is involved in both familial and sporadic Parkinson's disease. 29702063 2018
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE Genetic mouse models based on alpha-synuclein overexpression are particularly compelling because abnormal accumulation of alpha-synuclein occurs in sporadic Parkinson's disease (PD). 18585084 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE Novel A18T and pA29S substitutions in α-synuclein may be associated with sporadic Parkinson's disease. 23916651 2013
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 AlteredExpression disease BEFREE These findings reveal a significant additional mechanism by which alpha-synuclein is regulated and point toward new therapeutic regimes for lowering endogenous alpha-synuclein levels in patients with familial or sporadic Parkinson disease. 20106983 2010