Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 GeneticVariation disease BEFREE Mutations in the human Parkin gene, PRKN, leads to degeneration of dopaminergic (DA) neurons, resulting in autosomal recessive early-onset parkinsonism and the loss of PRKN function is linked to sporadic Parkinson's disease (PD). 31404530 2019
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 GeneticVariation disease BEFREE Therefore, we investigated their role in eye movement preparation in sporadic Parkinson's disease and in a very infrequent variant affecting the Parkin gene. 29769545 2018
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 AlteredExpression disease BEFREE In addition, gene knock-down/out of MIDN caused down-regulation of parkin E3 ubiquitin ligase, indicating MIDN to be a novel PD-risk factor or causative gene. 29311479 2018
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 GeneticVariation disease BEFREE Second mutation in PARK2 is absent in patients with sporadic Parkinson's disease and heterozygous exonic deletions/duplications in parkin gene. 27798970 2017
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 GeneticVariation disease BEFREE Exon dosage analysis of parkin gene in Chinese sporadic Parkinson's disease. 26240990 2015
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 GeneticVariation disease BEFREE Genetic analysis revealed a heterozygous PARKIN exon 3-4 deletion, also present in 2 family members with early-onset PD. 24375549 2014
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 GeneticVariation disease BEFREE Analysis of PARK2 gene exon rearrangements in Russian patients with sporadic Parkinson's disease. 21915905 2012
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 GeneticVariation disease BEFREE Mutations in the parkin gene cause autosomal-recessive, juvenile-onset parkinsonism, and parkin dysfunction may also play a role in the pathogenesis of sporadic Parkinson disease (PD). 19050041 2009
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 GeneticVariation disease BEFREE Geographic and ethnic differences in frequencies of two polymorphisms (D/N394 and L/I272) of the parkin gene in sporadic Parkinson's disease. 16269266 2005
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 GeneticVariation disease BEFREE Similar results were obtained when the cells were treated with a proteasome inhibitor, MG132.Furthermore, in a case control study involving 753 subjects, we demonstrated that the parkin promoter -258G variant was associated with an increased risk of sporadic Parkinson's disease (PD) in the elderly ethnic Chinese population. 16244875 2005
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 AlteredExpression disease BEFREE Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. 15252205 2004
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 GeneticVariation disease BEFREE In contrast to reports in oriental populations, our results do not support a major role of APOE, PARKIN and COMT polymorphisms in PD susceptibility in the Finnish population. 12270650 2002
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 GeneticVariation disease BEFREE Polymorphisms of the parkin gene in sporadic Parkinson's disease among Chinese in Taiwan. 10965160 2000
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 GeneticVariation disease BEFREE Polymorphism in the parkin gene in sporadic Parkinson's disease. 10319889 1999
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 GeneticVariation disease BEFREE Association of codon 167 Ser/Asn heterozygosity in the parkin gene with sporadic Parkinson's disease. 10511432 1999