Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE Furthermore, to enhance the pathological properties of α-synuclein, we inserted into SNCA an A53T mutation, two single-nucleotide polymorphisms identified in a genome-wide association study in Parkinson's disease and a Rep1 polymorphism, all of which are causal of familial Parkinson's disease or increase the risk of sporadic Parkinson's disease. 31816026 2020
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Recent research has focused on neuroinvasive influenza A viruses (IAV), whereas a genetic link between sPD and tuberculosis has arisen in LRRK2 - dependent maturation of the phagosome. 31765844 2020
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Human genetics studies have linked LRRK2 as a major genetic contributor to familial and sporadic Parkinson's disease (PD), a neurodegenerative movement disorder that inflicts millions worldwide. 30635421 2019
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE In this review, we focus on the recent advances on the role of Rab GTPases in the biology of two main proteins involved in Parkinson's disease: LRRK2 and α-synuclein, given that mutations in their genes (LRRK2 and SNCA) cause familial and sporadic Parkinson's disease. 31054512 2019
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE We demonstrate that these organoids can recapitulate the 3D pathological hallmarks observed in patients with LRRK2-associated sporadic Parkinson's disease. 30799274 2019
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE LRRK2 links genetic and sporadic Parkinson's disease. 30837320 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE Dopamine Cytotoxicity on SH-SY5Y Cells: Involvement of α-Synuclein and Relevance in the Neurodegeneration of Sporadic Parkinson's Disease. 30806984 2019
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Leucine-rich repeat kinase 2 (LRRK2) is a molecule associated with familial and sporadic Parkinson's disease. 31555076 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE In this review, we focus on the recent advances on the role of Rab GTPases in the biology of two main proteins involved in Parkinson's disease: LRRK2 and α-synuclein, given that mutations in their genes (LRRK2 and SNCA) cause familial and sporadic Parkinson's disease. 31054512 2019
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE Mutations in LRRK2 cause autosomal dominant and sporadic Parkinson's disease but the mechanisms involved in LRRK2 toxicity in PD are yet to be fully understood. 31626293 2019
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 GeneticVariation disease BEFREE Mutations in the human Parkin gene, PRKN, leads to degeneration of dopaminergic (DA) neurons, resulting in autosomal recessive early-onset parkinsonism and the loss of PRKN function is linked to sporadic Parkinson's disease (PD). 31404530 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 AlteredExpression disease BEFREE There appears to be an inverse relationship between glucocerebrosidase and α-synuclein levels, and even patients with sporadic Parkinson disease have decreased glucocerebrosidase. 31464647 2019
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene account for most common causes of familial and sporadic Parkinson's disease (PD) and are one of the strongest genetic risk factors in sporadic PD. 29894679 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE Role of Sporadic Parkinson Disease Associated Mutations A18T and A29S in Enhanced α-Synuclein Fibrillation and Cytotoxicity. 28841377 2018
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 GeneticVariation disease BEFREE Therefore, we investigated their role in eye movement preparation in sporadic Parkinson's disease and in a very infrequent variant affecting the Parkin gene. 29769545 2018
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE Mutations in leucine-rich repeat kinase 2 gene (<i>LRRK2</i>) are associated with familial and sporadic Parkinson's disease (PD). 29541021 2018
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE Recently, toxic α-synuclein oligomer, which can mediate cell-to-cell propagation is suggested to cause sporadic Parkinson disease. 29892158 2018
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 Biomarker disease BEFREE Our study suggests that Rab GTPases might mediate LRRK2 toxicity in the progression of PD. 29439717 2018
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE α-synuclein is involved in both familial and sporadic Parkinson's disease. 29702063 2018
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.100 GeneticVariation disease BEFREE LRRK2 p.G2385R is an Asian specific genetic risk factor for sporadic Parkinson's disease. 29414410 2018
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE Although usually sporadic, Parkinson's disease can result from inherited copy number variants in SNCA and other genes. 29917054 2018
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE This report demonstrates insoluble alpha-synuclein (aSYN)+ aggregates in human sporadic Parkinson's disease (PD) midbrain that are linearly correlated with loss of glucocerebrosidase (GCase) activity. 30315256 2018
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 GeneticVariation disease BEFREE A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease. 30146727 2018
Entrez Id: 5071
Gene Symbol: PRKN
PRKN
0.100 AlteredExpression disease BEFREE In addition, gene knock-down/out of MIDN caused down-regulation of parkin E3 ubiquitin ligase, indicating MIDN to be a novel PD-risk factor or causative gene. 29311479 2018
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE The total αSyn concentration in dental calculus is not a suitable biomarker for sporadic PD. 29600388 2018