Previous HNF1β research focused on the renal distal convoluted tubule (DCT) to elucidate the ADTKD-HNF1β electrolyte phenotype, although 70% of Mg<sup>2+</sup> is reabsorbed in the thick ascending limb of Henle's loop (TAL).
<b>Introduction:</b> Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a rare genetic cause of renal impairment resulting from mutations in the <i>MUC1, UMOD, HNF1B, REN</i>, and <i>SEC61A1</i> genes.
A locus for FJHN was previously identified on chromosome 16p12 close to the MCKD2 locus, which is responsible for a variety of autosomal-dominant medullary cystic kidney disease (MCKD2).