Gene: APOE ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.100 GeneticVariation disease BEFREE A total of 100 adults with DS (ages 35 to 79 years), almost all of whom were longitudinally assessed by neurologists, underwent APOE genotyping. 10430422 1999
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.100 GeneticVariation disease BEFREE We investigated whether sex differences in age at onset and risk of AD among adults with DS are similar to those observed in the general population and whether the effect of sex on risk of AD is modified by apolipoprotein E (APOE) genotype. 9566384 1998
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.100 Biomarker disease BEFREE The lower frequency of ApoE e4 in our older DS sample compared to population controls points to a detrimental effect of the e4 allele on longevity. 9532343 1998
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.100 Biomarker disease BEFREE In the present study we genotyped apoE and determined the origin of non-disjunction of 132 mothers and the corresponding fathers and DS children from Spain. 9665649 1998
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.100 Biomarker disease BEFREE It is very likely that the ApoE epsilon4 is a risk factor for DAT even in DS patients with a genetic predisposition to Alzheimer's disease. 9635475 1998
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.100 GeneticVariation disease BEFREE The apolipoprotein E epsilon4 allele causes a faster decline of cognitive performances in Down's syndrome subjects. 9073034 1997
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.100 AlteredExpression disease BEFREE Plasma apoE levels for DS patients did not differ significantly from those of controls (P > 0.05). 9058415 1997
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.100 Biomarker disease BEFREE Allelic variability in D21S11, but not in APP or APOE, is associated with cognitive decline in Down syndrome. 9189907 1997
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.100 GeneticVariation disease BEFREE We performed a meta-analysis of 11 published DS series for which apoE genotype data were available. 9427308 1997
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.100 GeneticVariation disease BEFREE Inheritance of the apolipoprotein E (ApoE) epsilon 4 allele is a risk factor for Alzheimer's disease (AD) and is associated with increased deposition of beta-amyloid (A beta) in AD, Down's syndrome, and normal aging. 9066363 1997
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.100 GeneticVariation disease BEFREE Compared with those with an apoE 3/3 genotype, the group of adults with DS with apoE 2/4, 3/4, and 4/4 genotypes were 5 times more likely to become demented (RR = 4.7; 95% CI = 1.2, 17.9). 8957023 1996
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.100 GeneticVariation disease BEFREE As described in other studies, the impact of the different APOE alleles in DS is modest. 8977148 1996
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.100 GeneticVariation disease BEFREE We examined the distribution of apoE alleles in people with DS and their parents. 8622392 1996
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.100 Biomarker disease BEFREE Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. 9173910 1996
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.100 GeneticVariation disease BEFREE Neuropathological changes in Down's syndrome hippocampal formation. Effect of age and apolipoprotein E genotype. 7710373 1995
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.100 Biomarker disease BEFREE These findings suggest that ApoE epsilon 4 does not significantly affect the pathogenesis of AD in DS patients. 7654070 1995
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.100 GeneticVariation disease BEFREE Apolipoprotein E epsilon 2 allele promotes longevity and protects patients with Down's syndrome from dementia. 7696609 1994