Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 GeneticVariation disease BEFREE Haplotype analysis showed that individuals with Tau H1/H1 and ApoEɛ4 genotypes were more prevalent among DS participants with an earlier diagnosis of dementia (17%) compared to H1/H2 haplotypes (6%). 30909239 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 GeneticVariation disease BEFREE A higher frequency of the APOE ε4 allele has been reported among young mothers giving birth to Down syndrome children. 28767121 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 GeneticVariation disease BEFREE We found no connection between apolipoprotein E genotype and the clinical course of DS. 27067497 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 GeneticVariation disease BEFREE Further research should include a large sample of adults with DS selected on diagnosed painful conditions to obtain more insight into the possible role of ApoE genotype (and its association with cognition) in the pain experience of this target group. 27193365 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 GeneticVariation disease BEFREE Similar efforts are occurring in an extended Colombian family with a PSEN1 mutation, in APOE ε4 homozygotes, and in Down syndrome. 25217249 2014
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 Biomarker disease BEFREE APOE4 is a major genetic risk factor for Alzheimer disease and is associated with dementia in Down syndrome and poor neurological outcome after traumatic brain injury, cerebral hemorrhage, and other neuropathological disorders. 23400708 2013
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 GeneticVariation disease BEFREE We tested for association with loci previously associated with Alzheimer's disease risk and, despite the small size of the study, we detected associations with age at onset of Alzheimer's disease in Down syndrome with PICALM (β = 3.31, p = 0.011) and the APOE loci (β = 3.58, p = 0.014). 23601808 2013
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 Biomarker disease BEFREE APOE4 is a major genetic risk factor for Alzheimer's disease and is associated with Down's syndrome dementia and poor neurological outcome after traumatic brain injury and haemorrhage. 22622580 2012
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 GeneticVariation disease BEFREE As expected, the most strongly associated SNP was the APOE ɛ4 rs429358 variant (HR=2.47 [1.58, 3.87], p=7.52×10(-5)), although variants within the more recently implicated SORL1 and RUNX1 genes were also strongly associated with DAD in DS (HR=0.54 [0.37, 0.80], p=0.002 and HR=1.61 [1.15, 2.26], p=0.006 respectively). 20946940 2011
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 GeneticVariation disease BEFREE To investigate the relation of plasma levels of Abeta peptides (Abeta1-40 and Abeta1-42) and apolipoprotein E (APOE) genotype to dementia status, and the duration of Alzheimer's disease (AD) in adults with Down syndrome (DS). 19513990 2010
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 GeneticVariation disease BEFREE To study the relationship between plasma levels of amyloid beta (Abeta) peptides and dementia in aging individuals with Down syndrome, we investigated the relationship among plasma Abeta, apolipoprotein E genotype and cognitive and clinical factors using baseline specimens form participants in an ongoing clinical trial in individuals with Down syndrome 50 years of age and older. 19571732 2010
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 Biomarker disease BEFREE We conclude that APOE is influencing the risk of dementia in persons with DS. 17250929 2008
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 GeneticVariation disease BEFREE The effect of allelic variants of Apolipoprotein (APOE) gene in development and progression of DAD and mortality in persons with DS is examined. 18464295 2008
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 GeneticVariation disease BEFREE These results highlight DS as a model to understand the role of APOE4 allele in unsuccessful ageing considering that a number of proinflammatory supernumerary genes (Cu/Zn superoxide dismutase, Ets-2 transcription factors, Down syndrome critical region 1, stress-inducible factor, interferon-alpha receptor and the amyloid precursor protein) are located on chromosome 21 and are implied in the pathologic processes of DS. 17559337 2007
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 Biomarker disease BEFREE Genomic DNA was prepared from blood samples to obtain ApoE status for the DS participants. 15345810 2004
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 Biomarker disease BEFREE Our findings suggest that the -850T allele, which is more common among patients at high risk of dementia such as those with DS, might eventually play a role in the development of dementia; no inference on the role of the allele APOE E4 in DS-related dementia may be derived from our results. 14615042 2003
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 Biomarker disease BEFREE As hepatitis B virus (HBV) infection and hypothyroidism also are common in DS, we evaluated associations between ApoE type, HBV status, and thyroid status in a sample of older persons with DS (n = 55; mean age, 44.3 +/- 10.8 years) using chi-squared analysis. 12833399 2003
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 Biomarker disease BEFREE ApoE4 frequency was significantly lower in DS when compared to AD patients. 12525890 2003
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 Biomarker disease BEFREE Allele varepsilon4 of apolipoprotein E gene is less frequent in Down syndrome patient of the Sicilian population and has no influence on the grade of mental retardation. 11403974 2001
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 AlteredExpression disease BEFREE Plasma levels of Abeta 40 and 42 did not correlate with apoE genotypes in DS and control cases, and with the extent of mental retardation in DS subjects. 11102927 2000
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 GeneticVariation disease BEFREE Because the apolipoprotein E (ApoE) E4 allele is a risk factor for AD and possibly also for dementia of the AD type in DS, DNA samples were also ApoE genotyped. 10861683 2000
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 GeneticVariation disease BEFREE Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. 10880397 2000
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 GeneticVariation disease BEFREE The observed apoE allele epsilon 3 frequencies among patients with Down syndrome and healthy control subjects may help explain and support previous work that did not find high rates of atherosclerosis among these persons. 10761455 2000
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 GeneticVariation disease BEFREE The APOE epsilon 4 allele acts as a risk factor for the age-specific manifestation of Alzheimer's disease in people with Down's syndrome. 10912224 2000
Entrez Id: 348
Gene Symbol: APOE
APOE
0.100 GeneticVariation disease BEFREE Apo E genotypes and risk of dementia in Down syndrome. 10402500 1999