Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1192
Gene Symbol: CLIC1
CLIC1 		0.040 Biomarker disease BEFREE Chloride intracellular channel 1 (CLIC1) was previously reported to be an effective biomarker for predicting the prognosis of GBC. 28944858 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.070 Biomarker disease BEFREE IL-6 and IL-10 were significantly increased in both the HCC and GBC groups, IL-2, IL-6, IL-10, and TNF-<i>α</i> in the cholangiocellular carcinoma group, and IL-2, IL-6, IL-8, and TNF-<i>α</i> in the pancreatic cancer group. 29410961 2017
Entrez Id: 140609
Gene Symbol: NEK7
NEK7 		0.010 Biomarker disease BEFREE NIMA-related kinase-7 (Nek7) is a centrosomal kinase involved in various types of cancer, including gallbladder cancer and hepatocellular carcinoma. 29434721 2018
Entrez Id: 407029
Gene Symbol: MIR30A
MIR30A 		0.010 Biomarker disease BEFREE MicroRNA-30a-5p inhibits gallbladder cancer cell proliferation, migration and metastasis by targeting E2F7. 29540696 2018
Entrez Id: 7052
Gene Symbol: TGM2
TGM2 		0.010 Biomarker disease BEFREE Transglutaminase 2 Mediates the Cytotoxicity of Resveratrol in a Human Cholangiocarcinoma and Gallbladder Cancer Cell Lines. 29757003 2018
Entrez Id: 8737
Gene Symbol: RIPK1
RIPK1 		0.030 Biomarker disease BEFREE RIP1 regulates TNF-α-mediated lymphangiogenesis and lymphatic metastasis in gallbladder cancer by modulating the NF-κB-VEGF-C pathway. 29844685 2018
Entrez Id: 10928
Gene Symbol: RALBP1
RALBP1 		0.030 Biomarker disease BEFREE RIP1 regulates TNF-α-mediated lymphangiogenesis and lymphatic metastasis in gallbladder cancer by modulating the NF-κB-VEGF-C pathway. 29844685 2018
Entrez Id: 7386
Gene Symbol: UQCRFS1
UQCRFS1 		0.030 Biomarker disease BEFREE RIP1 regulates TNF-α-mediated lymphangiogenesis and lymphatic metastasis in gallbladder cancer by modulating the NF-κB-VEGF-C pathway. 29844685 2018
Entrez Id: 6362
Gene Symbol: CCL18
CCL18 		0.010 Biomarker disease BEFREE CCL18 secreted from M2 macrophages promotes migration and invasion via the PI3K/Akt pathway in gallbladder cancer. 30276551 2019
Entrez Id: 960
Gene Symbol: CD44
CD44 		0.040 AlteredExpression disease BEFREE CD44 was overexpressed and associated with poor outcomes in GBC patients. 30288117 2018
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2 		0.100 GeneticVariation disease BEFREE ERBB2 and KRAS alterations mediate response to EGFR inhibitors in early stage gallbladder cancer. 30304546 2019
Entrez Id: 2065
Gene Symbol: ERBB3
ERBB3 		0.020 Biomarker disease BEFREE HER3 overexpression was predominantly cytoplasmic; the rate of overexpression/amplification of HER3 in membrane and cytoplasm was 16% [ampullary cancer (AMP) (1/13; 8%), gallbladder cancer (GBC) (1/10; 10%), intra-hepatic cholangiocarcinoma (ICC) (6/26; 23%), extra-hepatic cholangiocarcinoma (ECC) (3/18; 17%)] and 24% [AMP (1/13; 8%), GBC (1/10; 10%), ICC (10/26; 38%), ECC (4/18; 22%)], respectively. 30335866 2018
Entrez Id: 2040
Gene Symbol: STOM
STOM 		0.010 AlteredExpression disease BEFREE Stomatin-like protein-2 (SLP-2) gene belongs to the stomatin supergene family, and previous studies have revealed up-regulated SLP-2 expression in gallbladder cancer, lung cancer, and esophageal cancer, while the role of SLP-2 in colorectal cancer (CRC) remains unclear and needs further investigation. 30389319 2019
Entrez Id: 8842
Gene Symbol: PROM1
PROM1 		0.020 AlteredExpression disease BEFREE CD133 expression may be a useful marker for clinical prognosis in patients with EHBDCA and GBCA. 30405779 2018
Entrez Id: 727897
Gene Symbol: MUC5B
MUC5B 		0.010 Biomarker disease BEFREE MUC5B and CA9 are highly conserved during GBC histological progression. 30565710 2019
Entrez Id: 5300
Gene Symbol: PIN1
PIN1 		0.010 Biomarker disease BEFREE Pin1-mediated STAT3 and NF-κB activation induced EMT in GBC. 30610554 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 Biomarker disease BEFREE Tumor Protein p53 and K-ras Gene Mutations in Peruvian Patients with Gallbladder Cancer 30678452 2019
Entrez Id: 64241
Gene Symbol: ABCG8
ABCG8 		0.030 GeneticVariation disease BEFREE ABCG8 and TRAF3 variants also conferred risk to GBC. 30692554 2019
Entrez Id: 51366
Gene Symbol: UBR5
UBR5 		0.010 Biomarker disease BEFREE UBR5 may be an important biomarker for predicting the prognosis of patients with GBC. 30775814 2019
Entrez Id: 5820
Gene Symbol: PVT1
PVT1 		0.010 AlteredExpression disease BEFREE PVT1 was upregulated in GBC tissues and cells and was positively associated with malignancies and worse overall survival. 30825877 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1 		0.030 GeneticVariation disease BEFREE IDH1/2 mutations appeared more frequently in ICC (23.6%, P = 0.0002) than in GBC (4.0%) or ECC (2.3%), while ERBB2/3 mutations were found only in GBC (20.0%) and ECC (11.4%). 31476489 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2 		0.100 GeneticVariation disease BEFREE ERBB2 activating mutation occurs more frequently in GBC than ICA and ECA. 31558980 2019
Entrez Id: 693122
Gene Symbol: MIR421
MIR421 		0.010 AlteredExpression disease BEFREE MiR-421 overexpression led to increased migration and invasion rates of GBC. 31632058 2019
Entrez Id: 7351
Gene Symbol: UCP2
UCP2 		0.010 AlteredExpression disease BEFREE UCP2 knockdown suppressed the activation of the NF-κB/β-catenin axis and promoted the increases in mitochondrial ROS in gallbladder cancer cells exposed to gemcitabine treatments. 31811866 2020
Entrez Id: 1543
Gene Symbol: CYP1A1
CYP1A1 		0.080 GeneticVariation disease BEFREE A CYP1A1 polymorphism has been associated with an increased risk for gallbladder cancer (GBC) in Japanese women. 18990008 2009