×
Entrez Id:
3077
Gene Symbol:
HFE
HFE
0.100
GeneticVariation
disease
BEFREE
In the present study, biochemical and histopathological evidence of iron overload and HFE mutations was investigated in NASH patients.
12792703
2003
×
Entrez Id:
1571
Gene Symbol:
CYP2E1
CYP2E1
0.080
AlteredExpression
disease
BEFREE
Therefore, we measured hepatic CYP2E1 activity and its correlates in a cohort of nondiabetic patients with NASH (NDN) and controls to explore its role in the pathogenesis of human NASH .
12601351
2003
×
Entrez Id:
3553
Gene Symbol:
IL1B
IL1B
0.100
GeneticVariation
disease
BEFREE
Interleukin-1beta -511 T allele frequency and the T/T genotype frequency were significantly higher in NASH patients than those in control subjects.
15318095
2004
×
Entrez Id:
4547
Gene Symbol:
MTTP
MTTP
0.070
GeneticVariation
disease
BEFREE
Therefore, functional polymorphisms in MTP and MnSOD may be involved in determining susceptibility of NASH .
15094225
2004
×
Entrez Id:
3077
Gene Symbol:
HFE
HFE
0.100
GeneticVariation
disease
BEFREE
Therefore, our aim was to study the role of iron abnormalities and HFE gene mutations in patients with NASH .
15637751
2005
×
Entrez Id:
5465
Gene Symbol:
PPARA
PPARA
0.100
GeneticVariation
disease
BEFREE
Neither NASH nor genotype 1 HCV-related liver steatosis seems to be associated with the PPARalpha L162V polymorphism.
16297361
2005
×
Entrez Id:
9370
Gene Symbol:
ADIPOQ
ADIPOQ
0.100
Biomarker
disease
BEFREE
Adiponectin and adipoRII staining were lower in biopsies of subjects with NASH compared with simple steatosis.
15591515
2005
×
Entrez Id:
3162
Gene Symbol:
HMOX1
HMOX1
0.030
AlteredExpression
disease
BEFREE
The HO-1 expression was significantly increased in NASH patients and the increase reflected the severity of the disease.
15763346
2005
×
Entrez Id:
9370
Gene Symbol:
ADIPOQ
ADIPOQ
0.100
Biomarker
disease
BEFREE
Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis.
17006986
2006
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.100
AlteredExpression
disease
BEFREE
A significant correlation between mRNA CHIT and O2-, lipid peroxidation, TNFalpha , and ferritin levels was observed in both NASH and simple steatosis.
16825325
2006
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.100
Biomarker
disease
BEFREE
A significant correlation was observed also between CHIT, TNF-alpha and lipid peroxidation in both NASH and simple steatosis.
16848812
2006
×
Entrez Id:
9370
Gene Symbol:
ADIPOQ
ADIPOQ
0.100
AlteredExpression
disease
BEFREE
Serum adiponectin level was the only predictor of nonalcoholic steatohepatitis (NASH ) in this study (P=0.024).
16989692
2006
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.070
Biomarker
disease
BEFREE
The main aim of this study was to examine the relationship of the leptin system in steatosis and nonalcoholic steatohepatitis (NASH ).
17032406
2006
×
Entrez Id:
7040
Gene Symbol:
TGFB1
TGFB1
0.070
AlteredExpression
disease
BEFREE
There was a marked increase in gene expression of TGF-beta1 in patients with NASH (P=0.0002).
17032406
2006
×
Entrez Id:
3953
Gene Symbol:
LEPR
LEPR
0.030
AlteredExpression
disease
BEFREE
Increased expression was found for leptin receptor mRNA (P=0.0016) and its protein (P<0.05) in patients with NASH , especially those with fibrosis.
17032406
2006
×
Entrez Id:
1118
Gene Symbol:
CHIT1
CHIT1
0.020
AlteredExpression
disease
BEFREE
In addition, we found that CHIT over-expression influenced hepatic stellate cells activation, as demonstrated by the significant correlation between CHIT and alpha-SMA expression in NASH patients.
16848812
2006
×
Entrez Id:
1118
Gene Symbol:
CHIT1
CHIT1
0.020
Biomarker
disease
BEFREE
A significant correlation between mRNA CHIT and O2-, lipid peroxidation, TNFalpha, and ferritin levels was observed in both NASH and simple steatosis.
16825325
2006
×
Entrez Id:
79602
Gene Symbol:
ADIPOR2
ADIPOR2
0.020
AlteredExpression
disease
BEFREE
To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level.
17006986
2006
×
Entrez Id:
51094
Gene Symbol:
ADIPOR1
ADIPOR1
0.010
AlteredExpression
disease
BEFREE
To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level.
17006986
2006
×
Entrez Id:
3077
Gene Symbol:
HFE
HFE
0.100
GeneticVariation
disease
BEFREE
The aim of this study was to examine the relationship between HFE mutations and histological severity in a large North American multicenter cohort with NASH .
17680648
2007
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.100
GeneticVariation
disease
BEFREE
In the multivariate analysis, TNF-alpha promoter polymorphisms proved to be significant independent factors distinguishing NASH from simple steatosis.
17395331
2007
×
Entrez Id:
26503
Gene Symbol:
SLC17A5
SLC17A5
0.100
GeneticVariation
disease
BEFREE
In multivariate analysis, triglyceride and HDL cholesterol were predictors of NASH in patients with genotype 1, whereas in patients with genotype 3, AST was the only predictor.
17659580
2007
×
Entrez Id:
5468
Gene Symbol:
PPARG
PPARG
0.090
Biomarker
disease
BEFREE
In conclusion, the results confirmed involvement of the PPARgamma pathway in NASH and the therapeutic utility of a PPARgamma ligand.
17928738
2007
×
Entrez Id:
1571
Gene Symbol:
CYP2E1
CYP2E1
0.080
AlteredExpression
disease
BEFREE
We investigated whether the noninvasive determination of CYP2E1 activity could replace a liver biopsy in order to differentiate NASH from NAFL.
17617119
2007
×
Entrez Id:
4547
Gene Symbol:
MTTP
MTTP
0.070
GeneticVariation
disease
BEFREE
MTP -493 G/T polymorphism may impact NASH by modulating postprandial lipemia and lipoprotein metabolism; homozygous GG carriers have a more atherogenic postprandial lipid profile than the other genotypes, independently of adipokines and insulin resistance.
17464986
2007