Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 53345
Gene Symbol: TM6SF2
TM6SF2
0.080 Biomarker disease BEFREE Multivariate analyses adjusted for age, sex, smoking status, PNPLA3, TM6SF2, and VAT/SAT areas demonstrated an independent and dose-dependent relationship between the body size-metabolic phenotype and NASH or significant fibrosis. 31535207 2020
Entrez Id: 53345
Gene Symbol: TM6SF2
TM6SF2
0.080 GeneticVariation disease BEFREE Second, although the strongest genetic risk alleles for NAFLD (ie, the 148Met allele in PNPLA3 and the 167Lys allele in TM6SF2) are associated with increased liver fat content and progression to NASH and cirrhosis, these alleles are also unexpectedly associated with an apparent protection from cardiovascular disease. 30174213 2019
Entrez Id: 53345
Gene Symbol: TM6SF2
TM6SF2
0.080 Biomarker disease BEFREE PNPLA3 and TM6SF2 determine the risk of NASH and significant fibrosis, even after adjustment for insulin resistance, and exert an additive effect on NASH and significant fibrosis. 29193269 2018
Entrez Id: 53345
Gene Symbol: TM6SF2
TM6SF2
0.080 GeneticVariation disease BEFREE Interestingly, patients harbouring the TM6SF2 rs58542926 T allele that predispose to NAFLD/NASH had higher LBP level. 28464257 2017
Entrez Id: 53345
Gene Symbol: TM6SF2
TM6SF2
0.080 GeneticVariation disease BEFREE PNPLA3 genotypes partly affected the definition of NASH by the NAFLD activity score, but TM6SF2 genotypes did not affect the definition of NASH. 26610348 2016
Entrez Id: 53345
Gene Symbol: TM6SF2
TM6SF2
0.080 GeneticVariation disease BEFREE Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study. 26457389 2016
Entrez Id: 53345
Gene Symbol: TM6SF2
TM6SF2
0.080 GeneticVariation disease BEFREE Recently, genome-wide association studies led to the identification of the major inherited determinants of hepatic fat accumulation: patatin-like phospholipase domain-containing 3 (PNPLA3) I148M gene and transmembrane 6 superfamily member 2 (TM6SF2) E167K gene variants, involved in lipid droplets remodelling and very low-density lipoproteins secretion, are the major determinants of interindividual differences in liver steatosis, and susceptibility to progressive NASH. 26273621 2015
Entrez Id: 53345
Gene Symbol: TM6SF2
TM6SF2
0.080 GeneticVariation disease BEFREE In this study, we aimed to assess whether TM6SF2 E167K affects liver damage and cardiovascular outcomes in subjects at risk of NASH. 25251399 2015