Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE The results showed that genistein could reduce TLR4 protein and gene expression, decrease the endotoxin and TNFα, alleviate the inflammatory reaction and make the indicators detected in blood and liver stay near normal in NASH rats. 30841442 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression disease BEFREE Tumor necrosis factor-α (TNFα), known to be increased in NASH, induced AATF expression. 30394550 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE Ablation of TNFα in miR-378-treated mice impaired the ability of miR-378 to facilitate hepatic inflammation and fibrosis, suggesting that TNFα signaling is required for miR-378 to promote NASH. 30218679 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE Exposure of these cells to lipogenic (insulin, glucose, fatty acids) and pro-inflammatory factors (IL-1β, TNF-α, TGF-β) resulted in a characteristic NASH response, as indicated by intracellular lipid accumulation, modulation of NASH-specific gene expression, increased caspase-3/7 activity and the expression and/or secretion of inflammatory markers, including CCL2, CCL5, CCL7, CCL8, CXCL5, CXCL8, IL1a, IL6 and IL11. 31028903 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression disease BEFREE The positive effects observed for SAR on NASH are due to the downregulation of the LPS/TLR4 pathway, as indicated by the suppression of hepatic Toll-like receptor 4 (TLR4), NF-κB, TNF-α, and transforming growth factor-β1 (TGF-β1) expression. 30737662 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE Of interest, both TNF-α and type 1 IFN promoted apoptosis of Treg cells involved in the prevention of NASH. 30125542 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE Meanwhile, our study suggests that restoration of systemic and intestinal vitamin D deficiency using by chronic vitamin D treatment effectively reduces TNFα-mediated immunological abnormalities associated with the gut-adipose tissue-liver axis and hepatic steatosis in NASH rats. 29684027 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression disease BEFREE The serum levels of TNF-α and IL-6 were significantly increased in the novel NASH model group, and mice in this group exhibited histopathological features and insulin resistance reflective of NASH, i.e., macrovesicular hepatic steatosis, ballooning hepatocytes, Mallory-Denk bodies, lobular inflammation and fibrosis. 29154469 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE Previously, we have shown that the adipocyte-specific nuclear form of sterol regulatory element-binding protein-1c (nSREBP-1c) transgenic mice spontaneously developed hepatic lesions that are similar to those of human nonalcoholic steatohepatitis (NASH) with a concomitant elevation of plasma TNF-α. 28922680 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression disease BEFREE AMSC-EVs significantly decreased the number of Kupffer cells (KCs) in the liver of rats with NASH and the mRNA expression levels of inflammatory cytokines such as tumor necrosis factor- (<i>Tnf-</i>) <i>α</i>, interleukin- (<i>Il-</i>) <i>1β</i> and <i>Il-6</i>, and transforming growth factor- (<i>Tgf-</i>) <i>β</i>. 30675167 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression disease BEFREE Although augmented TNF-α production leads to temporal reduction of PEDF expression in NASH, PEDF conversely abrogates TNF-α-mediated hepatocyte death by modulating the extrinsic apoptosis pathway. 29897812 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE The study aimed to investigate the levels of proinflammatory (TNF-<i>α</i> and IL-6) along with anti-inflammatory cytokine IL-10 in patients with NASH and to correlate the cytokines' level with their polymorphism. 28852433 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE CGS21680 inhibited NASH development in steatotic mice and decreased cytokines and chemokines involved in Th cell recruitment or polarization (namely CXCL10, CCL2, tumor necrosis factor alfa [TNFα], tumor growth factor [TGFβ], and IL-12). 28011152 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE Inflammatory (TNF, LPS, IL-6) and profibrotic mediators (TGF-beta) do not regulate TUBA8 in HepG2 cells, primary HSC and the HSC cell line LX-2, when stimulated for 24 h. Agonists of the farnesoid X receptor and peroxisome proliferator activated receptor gamma, which are nuclear receptors involved in NASH and HCC pathophysiology, have no effect on TUBA8 in HepG2 and LX-2 cells. 28063004 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 PosttranslationalModification disease BEFREE However, GTE in HF mice decreased biochemical and histological parameters of NASH and lowered hepatic p65 phosphorylation in association with decreased serum TNFα, mRNA expression of TNFR1 and TLR4 and MyD88 protein. 28038359 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE BP reduced hepatic inflammation and apoptosis by affecting IL-6 (interleukin 6), TNF-α (Tumor necrosis factor α), caspase-3 and Bcl-2 in NASH models. 28264426 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression disease BEFREE The area under the receiver operating characteristic (AUROC) of the pyroglutamate levels of NASH versus SS patients was more than those of tumor necrosis factor-α, adiponectin and interleukin-8. 28842175 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE As the disruption of endoplasmic reticulum (ER) homeostasis is linked to animal models of fatty liver disease, we investigated the effects of these OT models on the proteins related to ER stress (i.e., BiP, inositol-requiring enzyme 1, protein kinase RNA-like endoplasmic reticulum kinase, eIF2alpha, ATF6beta, and glucose-regulated protein 94) and apoptosis (C/EBP-homologous protein, Caspase-3, 4, and 12, Bax, and tumor necrosis factor receptor-associated factor 2) in livers of C57BL/6 mice. 29018408 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression disease BEFREE Decreased miR-144 could enhance TNF-α and IFN-γ production by targeting TLR2 in vitro, and might contribute to TLR2 up-regulation and the progression of NASH in HFD-MetS E3 rats. 25534427 2015
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE Thus, MetS-induced NASH in HFD rabbits plays an active role in the pathogenesis of ED, likely through TNFα, as indicated by treatments reducing liver and circulating TNFα levels (T or OCA), or neutralizing TNFα action (infliximab), which significantly improve penile responsiveness to Ach in HFD rabbits. 24486698 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression disease BEFREE high TNF-α mRNA levels, determined by RT-PCR, characterize patients with NASH. 23009757 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 AlteredExpression disease BEFREE Mean serum TNFα levels were elevated in the serum of simple steatosis and NASH patients compared to healthy controls, reaching significance in NASH patients. 22658783 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE Increase of TNFα-producing Kupffer cells is crucial for triggering NASH via monocyte recruitment. 23066023 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily, and has been identified as a novel mediator of fatty liver disease (FLD). 19629467 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 GeneticVariation disease BEFREE In the multivariate analysis, TNF-alpha promoter polymorphisms proved to be significant independent factors distinguishing NASH from simple steatosis. 17395331 2007