Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.100 GeneticVariation disease BEFREE MetS and fatty liver disease been associated with changes in adiponectin, soluble ST2 (sST2), chitinase 3-like 1 (Chi3L1), hyaluronic acid (HA), tissue inhibitor of metalloproteinase-1 (TIMP-1), lysyl oxidase-like-2 (LOXL2) and transforming growth factor β (TGF-β) concentrations in HIV-uninfected populations. 29746485 2018
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.100 Biomarker disease BEFREE These results showed the protective role of Ang-(1-7) in the development of NASH through an adiponectin-independent mechanism, which may be partially attributed to the activation of hepatic AMP-activated protein kinase pathway. 26992300 2017
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.100 GeneticVariation disease BEFREE The frequencies of adiponectin gene promoter-11377C/G(CG), -11377C/G (GG), GPx-1 gene C594T (CT) and C594T (TT) were 24.50%, 26.00%, 24.00%, and 25.50% in the NAFL group, 34.50%, 37.00%, 35.00%, and 36.00% in the NASH group, 42.00%, 46.00%, 43.50%, and 45.50% in the NAFHC group, and 14.00%, 14.50%, 13.00%, and 14.00% in the control group, respectively. 26897098 2016
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.100 AlteredExpression disease BEFREE Human liver PPARα gene expression negatively correlates with NASH severity, visceral adiposity and insulin resistance and positively with adiponectin. 25703085 2015
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.100 AlteredExpression disease BEFREE Adiponectin levels increased continuously in NASH patients, whereas NAFL patients plateaued at 4 weeks post-operatively. 23627434 2013
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.100 AlteredExpression disease BEFREE The p.148 M PNPLA3 variant was associated with decreased adiponectin mRNA levels in the VAT of obese patients (p < 0.05) even in the absence of NASH. 22898488 2012
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.100 AlteredExpression disease BEFREE The current data indicate that in NASH hepatic inflammation and fibrosis but not hepatic steatosis induce liver MMP-9 activity, and this induction seems to be related to the anti-inflammatory activity of adiponectin rather than its effect on hepatocellular MMP-9 expression. 21791204 2011
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.100 GeneticVariation disease BEFREE Variations in adiponectin levels could be an indicator of disease progression since inflammatory infiltrates are commonly associated with nonalcoholic steatohepatitis (NASH) in morbidly obese patients. 20041267 2010
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.100 AlteredExpression disease BEFREE Patients with NASH had significantly higher mRNA adiponectin levels and lower IL-6 levels than did those with a normal liver (P<0.05). 18376369 2008
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.100 AlteredExpression disease BEFREE Also, adiponectin levels were compared with those of a control group of 30 healthy volunteers with normal ultrasound findings of the upper abdomen who had no known NASH risk factors. 18029322 2008
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.100 Biomarker disease BEFREE The prevalence of adiponectin single-nucleotide polymorphisms (SNPs) 45GT and 276GT was assessed in 70 nonobese, nondiabetic, normolipidemic NAFLD patients and 70 healthy matched controls; the impact of the adiponectin SNPs was subsequently correlated to liver histology and postprandial adiponectin and lipoprotein responses to oral fat load in a subgroup of 30 biopsy-proven patients with NASH and 30 controls. 18311774 2008
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.100 Biomarker disease BEFREE Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis. 17006986 2006
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.100 AlteredExpression disease BEFREE Serum adiponectin level was the only predictor of nonalcoholic steatohepatitis (NASH) in this study (P=0.024). 16989692 2006
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.100 Biomarker disease BEFREE Adiponectin and adipoRII staining were lower in biopsies of subjects with NASH compared with simple steatosis. 15591515 2005