Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2153
Gene Symbol: F5
F5
0.200 Biomarker disease RGD The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats. 25200834 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.030 Biomarker disease BEFREE The differential expression of NPM1 along the normal colon-adenoma-carcinoma progression and its involvement in resisting p53 related senescent growth arrest in CRC cell lines implicate its role in supporting CRC tumorigenesis. 23536448 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.030 Biomarker disease BEFREE Based on the reported gatekeeper properties of TP53, which in colon adenoma is frequently altered to yield carcinoma, this implies that HNE is likely to contribute to cancer progression. 17192441 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.030 PosttranslationalModification disease BEFREE In addition, some cases show heterogeneity of the p53 gene in carcinoma in adenoma of the colon. 8062281 1994
Entrez Id: 142
Gene Symbol: PARP1
PARP1
0.020 AlteredExpression disease BEFREE PARP-1 expression is increased in colon adenoma and carcinoma and correlates with OGG1. 25526641 2014
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.020 GeneticVariation disease BEFREE Case-control study of vitamin D, dickkopf homolog 1 (DKK1) gene methylation, VDR gene polymorphism and the risk of colon adenoma in African Americans. 22022386 2011
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.020 GeneticVariation disease BEFREE Genetic polymorphisms in vitamin D receptor VDR/RXRA influence the likelihood of colon adenoma recurrence. 20145122 2010
Entrez Id: 142
Gene Symbol: PARP1
PARP1
0.020 AlteredExpression disease BEFREE LT97 human colon adenoma and HT29 human colon adenocarcinoma cells were used to investigate modulation of apoptosis by EPA, DHA or linoleic acid (LA) using a set of endpoints, namely phosphatidylserine staining with Annexin-V (flow cytometry), Bcl-2 expression (Real-time RT-PCR), and Bid, caspase 3, 8 and 9 expression as well as PARP cleavage (Western Blot). 20107900 2010
Entrez Id: 59352
Gene Symbol: LGR6
LGR6
0.010 AlteredExpression disease BEFREE The expression levels of LGR6 in colon adenoma and adenocarcinoma were significantly higher than those in normal colon epithelial tissues (P < 0.001). 29971639 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.010 Biomarker disease BEFREE Celecoxib - COX-2 selective inhibitor- showed efficacy in decreasing of colon adenoma recurrence only in some studies. 30149368 2018
Entrez Id: 3880
Gene Symbol: KRT19
KRT19
0.010 Biomarker disease BEFREE In this study, we aimed to evaluate the relationship between diverse biologic markers and a newly diagnosed CA and to predict the clinical possibility of cytokeratin-19 soluble in serum fragment (CYFRA 21-1) as a screening tool in asymptomatic adults aged over 45 years. 28186354 2018
Entrez Id: 86
Gene Symbol: ACTL6A
ACTL6A
0.010 AlteredExpression disease BEFREE The data from both the Gene Expression Omnibus (GEO) and Oncomine databases showed that ACTL6A expression levels in colon adenoma and cancer were higher than those in normal colon samples. 30348114 2018
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.010 AlteredExpression disease BEFREE These data support the hypothesis that adiponectin, IGF-1, and TNF-α high levels correlate with higher risk of colon adenoma and can thus be used for colorectal adenomas risk assessment. 29593647 2018
Entrez Id: 5142
Gene Symbol: PDE4B
PDE4B
0.010 AlteredExpression disease BEFREE Pde4b is one of the triply conserved transcripts whose level is enhanced both in the colonic adenoma and in the normal colonic epithelium, especially adjacent to adenomas. 30188895 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.010 AlteredExpression disease BEFREE These data support the hypothesis that adiponectin, IGF-1, and TNF-α high levels correlate with higher risk of colon adenoma and can thus be used for colorectal adenomas risk assessment. 29593647 2018
Entrez Id: 2867
Gene Symbol: FFAR2
FFAR2
0.010 Biomarker disease BEFREE Our results showed that FFAR2 deficiency promotes the development of colon adenoma in the Apc<sup>Min/+</sup> /DSS mice and the progression of adenoma to adenocarcinoma in the AOM/DSS mice. 29524208 2018
Entrez Id: 9407
Gene Symbol: TMPRSS11D
TMPRSS11D
0.010 Biomarker disease BEFREE Our study is of potential clinical interest because agents that promote or maintain histone acetylation through HDAC inhibition and/or HAT stimulation, may help to lower colon adenoma/carcinoma incidence, especially in high-risk families, or could be included in therapeutic protocols to treat advanced colon cancer. 28418886 2017
Entrez Id: 2305
Gene Symbol: FOXM1
FOXM1
0.010 AlteredExpression disease BEFREE Immunohistochemical assays were performed to detect FoxM1 and epithelial (E-) cadherin protein expression in 92 CRC, 61 colonic adenoma and 32 wild-type colonic tissue samples. 29163688 2017
Entrez Id: 346389
Gene Symbol: MACC1
MACC1
0.010 AlteredExpression disease BEFREE Increased MACC1 levels in tissues and blood identify colon adenoma patients at high risk. 27439755 2016
Entrez Id: 81839
Gene Symbol: VANGL1
VANGL1
0.010 Biomarker disease BEFREE Elevated Coexpression of KITENIN and the ErbB4 CYT-2 Isoform Promotes the Transition from Colon Adenoma to Carcinoma Following APC loss. 26527747 2016
Entrez Id: 2066
Gene Symbol: ERBB4
ERBB4
0.010 GeneticVariation disease BEFREE Elevated Coexpression of KITENIN and the ErbB4 CYT-2 Isoform Promotes the Transition from Colon Adenoma to Carcinoma Following APC loss. 26527747 2016
Entrez Id: 406958
Gene Symbol: MIR182
MIR182
0.010 AlteredExpression disease BEFREE Here, we show that miR-182 and miR-503 undergo sequential up-regulation and drive the progression of colon adenoma to adenocarcinoma by cooperatively down-regulating the tumour suppressor FBXW7. 25269767 2014
Entrez Id: 55294
Gene Symbol: FBXW7
FBXW7
0.010 Biomarker disease BEFREE Here, we show that miR-182 and miR-503 undergo sequential up-regulation and drive the progression of colon adenoma to adenocarcinoma by cooperatively down-regulating the tumour suppressor FBXW7. 25269767 2014
Entrez Id: 2627
Gene Symbol: GATA6
GATA6
0.010 AlteredExpression disease BEFREE The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression. 24952462 2014
Entrez Id: 5653
Gene Symbol: KLK6
KLK6
0.010 AlteredExpression disease BEFREE Kallikrein-related peptidase 6 (KLK6) expression in the progression of colon adenoma to carcinoma. 25153391 2014