Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 GeneticVariation disease BEFREE Most commonly, up to 25% of all PC-PGLs are associated with mutations in one of the succinate dehydrogenase (SDH) enzyme subunit genes. 31498738 2020
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 Biomarker disease BEFREE The Role of 68Ga-DOTA-Octreotate PET/CT in Follow-Up of SDH-Associated Pheochromocytoma and Paraganglioma. 30977831 2019
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 Biomarker disease BEFREE The succinate dehydrogenase (SDH) enzyme was proven to be the most important molecular pathway involved in pheochromocytomas, along with several other genes. 30456751 2018
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 GeneticVariation disease BEFREE In this study, we investigated mutations of SDH genes in six HPPS patients from four Japanese pedigrees using peripheral blood lymphocytes (from one patient with pheochromocytoma and five patients with neck paraganglioma) and tumor tissues (from two patients with paraganglioma). 29925701 2018
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 Biomarker disease BEFREE CT = computed tomography HNP = head and neck paraganglioma IQR = interquartile range PGL = paraganglioma PPGL = pheochromocytoma and paraganglioma SDH = succinate dehydrogenase. 27967220 2017
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 Biomarker disease BEFREE Clinical, biochemical, pathological attributes, and outcomes in the MEN-PCC group were correlated with the genotype, and further compared with non-MEN, apparently sporadic adrenal-PCCs (n = 132, excluding 37 extra-adrenal and 15 VHL/NF1/SDH-associated PCC). 26438242 2016
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 GeneticVariation disease BEFREE Transcriptional profiling analysis classified the tumor within cluster 2 of PCCs/PGLs (without SDH gene mutations) and identified downregulation of genes involved in neuronal development and homeostasis (NLGN4, CD99 and CSF2RA) as well as upregulation of Drosha, an important gene involved in miRNA and rRNA processing. 27209355 2016
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 Biomarker disease BEFREE Metabolome profiling by HRMAS NMR spectroscopy of pheochromocytomas and paragangliomas detects SDH deficiency: clinical and pathophysiological implications. 25622899 2015
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 Biomarker disease BEFREE The aim of this study was to investigate interobserver variability among seven expert endocrine pathologists using a web-based virtual microscopy approach in a large multicenter pheochromocytoma/paraganglioma cohort (n=351): (1) 73 SDH mutated, (2) 105 non-SDH mutated, (3) 128 samples without identified SDH-x mutations, and (4) 45 with incomplete SDH molecular genetic analysis. 25720320 2015
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 GeneticVariation disease BEFREE Mutations of the SDH gene are associated with many tumors, such as renal cell carcinoma, wild type gastrointestinal stromal tumors (WT GISTs) and hereditary paragangliomas/pheochromocytomas. 26722403 2015
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 GeneticVariation disease BEFREE IDH1 and IDH2 mutations are found in many neoplasms, and germline alterations in SDH genes and FH predispose to pheochromocytoma/paraganglioma and other cancers. 25766404 2015
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 Biomarker disease BEFREE Patients with germline mutations in one of the SDH genes are at substantially increased risk of developing paragangliomas, pheochromocytomas (pheos), and other tumors (all combined referred to as SDH-related tumors). 23934599 2014
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 GeneticVariation disease BEFREE Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/paraganglioma tumors. 24465590 2014
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 GeneticVariation disease BEFREE Usefulness of negative and weak-diffuse pattern of SDHB immunostaining in assessment of SDH mutations in paragangliomas and pheochromocytomas. 24096807 2013
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 GeneticVariation disease BEFREE Using the yeast model, here, we report functional investigations on several missense SDH mutations found in patients affected by pheochromocytomas or paragangliomas. 23175444 2013
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 Biomarker disease BEFREE The dysfunction of genes involved in the cellular response to hypoxia, such as VHL, EGL nine homolog 1, and the succinate dehydrogenase (SDH) genes, leads to a direct abrogation of hypoxia inducible factor (HIF) degradation, resulting in a pseudo-hypoxic state implicated in PCC/PGL development. 23418310 2013
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 GeneticVariation disease BEFREE Genetic analysis for PHEO/paraganglioma genes (SDH A-D, SDHAF2, RET, VHL, TMEM127, and MAX), and pituitary-related genes (AIP, MEN1, and p27) were negative. 23295290 2012
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 Biomarker disease BEFREE It is now recognized that all of the SDH genes are involved in the tumorigenesis of not only paragangliomas/pheochromocytomas, but also other tumor types, most notably gastrointestinal stromal tumors. 22692282 2012
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 GeneticVariation disease BEFREE The differing effect of the SDHD p.Pro81Leu on HNPGL and pheochromocytoma risks suggests differing mechanisms of tumorigenesis in SDH-associated HNPGL and pheochromocytoma. 19802898 2010
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 GeneticVariation disease BEFREE As SDH mutations are virtually always germline, we conclude that approximately 15% of all pheochromocytomas or paragangliomas are associated with germline SDH mutation and that immunohistochemistry can be used to triage genetic testing. 20236688 2010
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 GeneticVariation disease BEFREE The paraganglioma-pheochromocytoma syndrome is caused by germline-inactivating mutations in the mitochondrial succinate dehydrogenase (SDH) genes SDHB, SDHC, SDHD, or SDHAF2, and VHL is the result of inactivating VHL gene mutations. 19915015 2010
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 Biomarker disease BEFREE SDH-related pheochromocytoma and paraganglioma. 20833333 2010
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 Biomarker disease BEFREE Recent studies indicate that succinate dehydrogenase (SDH) genes B, C, or D are, at least partly, involved in the pathogenesis of pheochromocytoma or paraganglioma. 19550080 2009
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 GeneticVariation disease BEFREE Germline mutations in SDH genes are responsible for 6% and 9% of sporadic paragangliomas and phaeochromocytomas, respectively, 29% of paediatric cases, 38% of malignant tumours and more than 80% of familial aggregations of paraganglioma and phaeochromocytoma. 19522823 2009
Entrez Id: 10993
Gene Symbol: SDS
SDS
0.100 Biomarker disease BEFREE Mutations in genes encoding succinate dehydrogenase and its anchoring subunits (SDH genes) are at the origin of hereditary head and neck paraganglioma (PGL) and a subset of apparently sporadic pheochromocytoma. 19145771 2009