Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6389
Gene Symbol: SDHA
SDHA
0.200 GeneticVariation disease BEFREE Pathogenic germline SDHA variants were identified in 30 of the 393 referred patients with PGL (7.6%), who had head and neck PGL (21 of 174 [12%]), pheochromocytoma (4 of 191 [2%]), or sympathetic PGL (5 of 28 [18%]). 29177515 2018
Entrez Id: 6389
Gene Symbol: SDHA
SDHA
0.200 GeneticVariation disease BEFREE Of 972 unrelated registrants without mutations in the classic pheochromocytoma- and paraganglioma-associated genes (632 female [65.0%] and 340 male [35.0%]; age range, 8-80; mean [SD] age, 41.0 [13.3] years), 58 (6.0%) carried germline mutations of interest, including 29 SDHA, 20 TMEM127, 8 MAX, and 1 SDHAF2. 28384794 2017
Entrez Id: 6389
Gene Symbol: SDHA
SDHA
0.200 Biomarker disease BEFREE SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: a multicenter interobserver variation analysis using virtual microscopy: a Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T). 25720320 2015
Entrez Id: 6389
Gene Symbol: SDHA
SDHA
0.200 Biomarker disease BEFREE Although 14 different genes have been linked to paraganglioma/pheochromocytoma, a subgroup of these genes is associated with hereditary paraganglioma-pheochromocytoma, the genes related to mitochondrial succinate dehydrogenase (SDH) including SDHA, SDHB, SDHC, SDHD and the assembly factor SDHAF2. 26067997 2015
Entrez Id: 6389
Gene Symbol: SDHA
SDHA
0.200 GeneticVariation disease BEFREE Mutations in genes (SDHB, SDHD, SDHC, and SDHA) encoding a component of the tricarboxylic acid cycle, succinate dehydrogenase (SDH), are a major cause of inherited PCC and PGL. 25004247 2014
Entrez Id: 6389
Gene Symbol: SDHA
SDHA
0.200 GeneticVariation disease BEFREE We hypothesised that PC/PGLs containing SDHx or VHL mutations, and succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumours (GISTs), would overexpress miR-210 relative to non-SDH or -VHL-mutated counterparts. miR-210 was analysed by quantitative PCR in i) 39 PC/PGLs, according to genotype (one SDHA, five SDHB, seven VHL, three NF1, seven RET, 15 sporadic, one unknown) and pathology (18 benign, eight atypical, 11 malignant, two unknown); ii) 18 GISTs, according to SDHB immunoreactivity (nine SDH-deficient and nine SDH-proficient) and iii) two novel SDHB-mutant neurosphere cell lines. miR-210 was higher in SDHx- or VHL-mutated PC/PGLs (7.6-fold) compared with tumours without SDHx or VHL mutations (P=0.0016). miR-210 was higher in malignant than in unequivocally benign PC/PGLs (P=0.05), but significance was lost when benign and atypical tumours were combined (P=0.08). 24623741 2014
Entrez Id: 6389
Gene Symbol: SDHA
SDHA
0.200 GeneticVariation disease BEFREE About 60% of Pheochromocytoma (PCC) and Paraganglioma (PGL) patients have either germline or somatic mutations in one of the 12 proposed disease causing genes; SDHA, SDHB, SDHC, SDHD, SDHAF2, VHL, EPAS1, RET, NF1, TMEM127, MAX and H-RAS. 24466223 2014
Entrez Id: 6389
Gene Symbol: SDHA
SDHA
0.200 Biomarker disease BEFREE We have performed SDHB and SDHA immunohistochemical staining in a series of paragangliomas and pheochromocytomas from 64 patients. 24096807 2013
Entrez Id: 6389
Gene Symbol: SDHA
SDHA
0.200 Biomarker disease BEFREE SDHA and SDHB immunohistochemistry are reliable techniques to identify pheochromocytomas and paragangliomas with mutations in SDHA, SDHB, SDHC and SDHD. 23174939 2013
Entrez Id: 6389
Gene Symbol: SDHA
SDHA
0.200 AlteredExpression disease BEFREE We investigated 316 pheochromocytomas and paragangliomas for SDHA expression. 21752896 2011
Entrez Id: 6389
Gene Symbol: SDHA
SDHA
0.200 GeneticVariation disease BEFREE Pheochromocytomas and paragangliomas are neuroendocrine tumors that occur in the context of inherited cancer syndromes in ∼30% of cases and are linked to germline mutations in the VHL, RET, NF1, SDHA, SDHB, SDHC, SDHD, SDHAF2 and TMEM127 genes. 21784903 2011
Entrez Id: 6389
Gene Symbol: SDHA
SDHA
0.200 GeneticVariation disease BEFREE We also investigated 202 paragangliomas or pheochromocytomas for loss of heterozygosity (LOH) at the SDHA, SDHB, SDHC and SDHD loci by BAC array comparative genomic hybridization. 20484225 2010
Entrez Id: 6389
Gene Symbol: SDHA
SDHA
0.200 GeneticVariation disease BEFREE Here we introduce all reported paraganglioma and pheochromocytoma related sequence variations in these genes, in addition to all reported mutations of SDHA.The database is now accessible online. 16288654 2005
Entrez Id: 6389
Gene Symbol: SDHA
SDHA
0.200 Biomarker disease HPO