Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE PDL1 expression and its clinical relevance in sarcomas are not well understood. 24866169 2014
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE However, the unprecedented clinical activity and excellent safety profile of checkpoint inhibitors targeting programmed death-1 receptor and its ligand (PD-1/PD-L1) have galvanized the field and generated much enthusiasm to harness the power of immunotherapy in pursuit of cures in patients with advanced sarcomas. 25975445 2015
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE Our meta-analysis indicated that high PD-L1 expression is likely to be a negative factor for patients with sarcomas and that it predicts worse survival outcomes. 28938660 2017
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE We investigated this issue using genomically related, clonal subsets from the same methylcholanthrene-induced sarcoma: a highly immunogenic subset that is spontaneously eliminated in vivo by adaptive immunity and a less immunogenic subset that forms tumors in immunocompetent mice, but is sensitive to PD-1/PD-L1 blockade therapy. 28073774 2017
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE Expression and clinical association of programmed cell death-1, programmed death-ligand-1 and CD8<sup>+</sup> lymphocytes in primary sarcomas is subtype dependent. 29050367 2017
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE A lymphocytic infiltrate was present in 64% of the sarcomas in this immunocompetent model and 71% of tumors expressed PD-L1. 28841687 2017
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE Finally, we found that SARC-L1 is sensitive to several drugs commonly used to treat sarcoma and also susceptible to anti-PD-L1 monoclonal antibody therapy in vivo. 28430664 2017
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE We found that the expression of PD-L1 in sarcoma differs depending on the histologic subtype and the PD-L1 antibody clones. 30400799 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE Stata 12.0 software was applied to calculate the strength of association between PD-L1 expression and sarcoma.In total, 14 articles containing 15 independent studies and 1,451 patients were included in this meta-analysis. 29923984 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE In this review, we provide a brief overview of the mechanisms of action of immune checkpoint inhibitors and discuss the proposed biomarkers of therapy response, such as lymphocytic infiltration, intratumoral PD-L1 expression, and mutational load in sarcomas. 29155424 2018
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE Exceptionally rapid response to pembrolizumab in a SMARCA4-deficient thoracic sarcoma overexpressing PD-L1: A case report. 31617320 2019