Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 Biomarker group BEFREE Direct sequencing was historically the gold standard for mutation testing for EGFR, KRAS (Kirsten rat sarcoma viral oncogene homologue) and BRAF (v-Raf murine sarcoma viral oncogene homologue B1) requiring a high ratio of tumour to normal cells, but this has been superseded by more sensitive methods. 30636374 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation group BEFREE Activating BRAF (V-raf murine sarcoma viral oncogene homolog B) mutations occur in approximately 5% to 10% of patients with metastatic colorectal cancer, mostly V600E mutation, and it is associated with distinct clinical and pathological features. 27341594 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 Biomarker group BEFREE The rapid advances in the molecular biology and genetics have improved the understanding of molecular pathogenesis of v-Raf murine sarcoma viral oncogene homolog B (BRAF), feline sarcoma viral oncogene v-kit (KIT), and neuroblastoma v-Ras oncogene homolog (NRAS) mutant melanomas with the subsequent development of targeted therapeutic agents. 26825879 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 Biomarker group BEFREE BRAF (v-Raf murine sarcoma viral oncogene homolog B) mutations are identified in approximately 2% of non-small cell lung cancer (NSCLC). 26711930 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 Biomarker group BEFREE BRAF = v-raf murine sarcoma viral oncogene homolog B1 FLUS = follicular lesion of undetermined significance FNAB = fine-needle aspiration biopsy FTC = follicular thyroid carcinoma HRAS = homologous to the oncogene from the Harvey rat sarcoma virus KRAS = homologous to the oncogene from the Kirsten rat sarcoma virus NRAS = first isolated from a human neuroblastoma/neuroblastoma RAS = viral oncogene homolog PAX8 = paired box 8 PCR = polymerase chain reaction PPAR-gamma = peroxisome proliferator-activated receptor gamma PTC = papillary thyroid carcinoma RAS = rat sarcoma RET = rearranged during transfection tyrosine-kinase proto-oncogene SM = somatic mutation SNP = single-nucleotide polymorphism. 27214302 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation group BEFREE Approximately 2% of lung adenocarcinomas have BRAF (v-Raf murine sarcoma viral oncogene homolog B) mutations, including V600E and other types. 26200454 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation group BEFREE In histiocytic sarcoma, FDC sarcoma and LCH, there were no significant differences in clinical features between tumours containing BRAF(V600E) and those with BRAF(wt) . 24720374 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation group BEFREE One melanoma-sarcoma pair showed identical BRAF V600E mutations. 24117833 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation group BEFREE BRAF (v-raf murine sarcoma viral oncogene homologue B) V600E mutations have been detected with high frequency in melanocytic naevi. 25039578 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 Biomarker group BEFREE We performed mutational analysis of recurrent mutation sites of PIK3CA (exons 9 and 20), JAK2 (exon 14), BRAF (exon 15), FOXL2 (exon 1), IDH1 (exon 4), AKT1 (exon 3), and EZH2 (exon 16) genes in 108 sarcomas by single- strand conformation polymorphism and DNA sequencing. 22779686 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation group BEFREE Frequent somatic mutations of BRAF (v-raf murine sarcoma viral oncogene homolog B) exon T1799A, which are implicated in the initial events of promutagenic cellular proliferation, are detected in both malignant melanomas (MM) and melanocytic nevi (MN). 21326296 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation group BEFREE The v-raf murine sarcoma viral homolog B1 (BRAF) gene, one of the human isoforms of RAF, is activated by Ras, leading to cooperative effects in cells responsive to growth factor signals. 14691295 2003