Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE By RT-PCR, fusion transcripts involving CIC (19q13) and DUX4 (4q35) were confirmed to be present in both primitive round cell sarcomas, further defining the breakpoints seen by genomic analysis. 19837261 2009
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE The CIC-DUX4 fusion transcript is present in a subgroup of pediatric primitive round cell sarcomas. 21813156 2012
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 AlteredExpression group BEFREE High prevalence of CIC fusion with double-homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small blue round cell sarcomas. 22072439 2012
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE CIC-DUX4 sarcoma represents a novel translocation-associated sarcoma with distinctive histopathologic features and rapid disease progression. 23887164 2013
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE In conclusion, the distinct gene signature and immunoprofile of CIC-DUX4 sarcomas suggest a distinct pathogenesis from ES. 24723486 2014
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE In this review we discuss the main categories of undifferentiated round cell sarcoma, in relation to Ewing sarcoma and its molecular variants, with particular emphasis on the genetic and biologic features of recently described entities including desmoplastic small round cell tumor and CIC-DUX4 as well as BCOR-CCNB3-associated round cell sarcomas. 24801613 2014
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE These findings are cautionary regarding use of these immunostains in prospective case workup, whereas the prevalent MYC amplification may represent a therapeutically targetable oncogenic pathway in CIC-DUX sarcomas. 24947144 2015
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE Aside from the desmoplastic stroma, the CIC-FOXO4 fusion sarcoma showed morphologic and immunohistochemical similarity to ESFT and Ewing-like sarcomas, including the recently described CIC-DUX4 fusion sarcoma. 25007147 2014
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 GeneticVariation group BEFREE We evaluated BRG1 and INI1 expression in 12 SCCOHTs and in a series of 122 tumors that could mimic SCCOHT morphologically: 9 juvenile granulosa cell tumors, 47 adult granulosa cell tumors, 33 high-grade ovarian serous carcinomas, 9 desmoplastic round cell tumors, 13 Ewing sarcomas (5 from the pelvis and 8 from soft tissues), 1 round cell sarcoma associated with CIC-DUX4 translocation from soft tissue (thigh), 1 case of high-grade endometrial stromal sarcoma of the ovary, and 9 melanomas. 26135561 2015
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE This is the first case of sarcoma with CIC-DUX4 gene fusion reported in a patient with NF1. 26386605 2015
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE A histologic comparison of the CIC-rearranged sarcomas with 20 EWSR1-rearranged Ewing sarcomas showed significantly higher degrees of lobulation, nuclear pleomorphism, the prominence of the nucleoli, spindle cell elements, and myxoid changes in the CIC-rearranged sarcomas. 26685084 2016
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE Nonetheless, NKX2-2 may be helpful to distinguish Ewing sarcoma from some histologic mimics including CIC-DUX4 and BCOR-CCNB3 sarcomas. 26847175 2016
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE The spectrum of ELS is now expanding, and additional gene fusion partners besides DUX4 or CCNB3 have been detected, and the terms CIC or BCOR-rearranged sarcomas have recently been proposed. 27306060 2016
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 AlteredExpression group BEFREE In summary, diffuse moderate-to-strong ETV4 expression is present in most CIC-rearranged sarcomas and unclassified round cell sarcomas. 27443513 2016
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 AlteredExpression group BEFREE We performed a detailed immunohistochemical analysis to investigate ETV4 expression in CIC-rearranged undifferentiated round-cell sarcomas and their potential mimics (especially Ewing sarcomas). 27562494 2016
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 GeneticVariation group BEFREE A recently characterized group of undifferentiated small round cell sarcomas harbours fusions of the genes CIC and DUX4. 27790742 2017
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE The CIC-DUX4 sarcoma is a subset of the undifferentiated small round cell sarcoma family, presently recognized as a new clinicopathological entity. 27919577 2017
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE This case report describes an additional case of <i>CIC-DUX4</i> sarcoma with a novel fusion breakpoint, and demonstrates the value of this next-generation sequencing-based anchored multiplex PCR technique (Archer FusionPlex Sarcoma Panel) in both diagnosis for patient care and in identification of a novel fusion breakpoint in this tumour type. 28137728 2017
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 GeneticVariation group BEFREE We recognized the tumor as a genetically distinct variant of CIC-rearranged sarcomas with a novel NUTM2A-CIC fusion. 28188754 2017
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE Heterogeneous elements included a myxoid spindle cell component in three BCOR-CCNB3 sarcomas and an epithelioid cell component in two CIC-associated sarcomas (one CIC-DUX4-positive and one CIC-DUX4-negative sarcomas). 28197724 2017
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 GeneticVariation group BEFREE ETV transcriptional upregulation is more reliable than RNA sequencing algorithms and FISH in diagnosing round cell sarcomas with CIC gene rearrangements. 28233365 2017
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE As such the WHO classification temporarily grouped the CIC-rearranged tumors under undifferentiated sarcomas with round cell phenotype, until further clinical evidence was available. 28346326 2017
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE <i>CIC-DUX4</i> Induces Small Round Cell Sarcomas Distinct from Ewing Sarcoma. 28404587 2017
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE The diagnosis of sarcoma with CIC-DUX4 gene fusion is difficult in lack of specific pathological characteristics emphasizing the need for molecular analysis. 28466754 2019
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 GeneticVariation group BEFREE Primitive round- or spindle-cell EWSR1-negative undifferentiated sarcomas harboring CIC-DUX4 gene fusion are the most common form of Ewing-like sarcomas. 28474974 2019