Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE The CIC-DUX4 sarcoma is a small round blue cell sarcoma which presents like extraskeletal Ewing sarcoma, but is negative for the EWSR1 gene translocation. 30353686 2018
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE The diagnosis of sarcoma with CIC-DUX4 gene fusion is difficult in lack of specific pathological characteristics emphasizing the need for molecular analysis. 28466754 2019
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE The spectrum of ELS is now expanding, and additional gene fusion partners besides DUX4 or CCNB3 have been detected, and the terms CIC or BCOR-rearranged sarcomas have recently been proposed. 27306060 2016
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE These findings are cautionary regarding use of these immunostains in prospective case workup, whereas the prevalent MYC amplification may represent a therapeutically targetable oncogenic pathway in CIC-DUX sarcomas. 24947144 2015
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE This case report describes an additional case of <i>CIC-DUX4</i> sarcoma with a novel fusion breakpoint, and demonstrates the value of this next-generation sequencing-based anchored multiplex PCR technique (Archer FusionPlex Sarcoma Panel) in both diagnosis for patient care and in identification of a novel fusion breakpoint in this tumour type. 28137728 2017
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE This is the first case of sarcoma with CIC-DUX4 gene fusion reported in a patient with NF1. 26386605 2015
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE Unsupervised clustering by RNAseq data revealed that tumors with BCOR genetic alterations, including BCOR-CCNB3, BCOR-MAML3, and BCOR ITD, formed a tight genomic group distinct from ES and CIC-rearranged sarcomas. 29300189 2018
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 Biomarker group BEFREE We estimated that the FISH false-negative rate for CIC-rearranged sarcomas was 14%. 28493604 2017
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 GeneticVariation group BEFREE We evaluated BRG1 and INI1 expression in 12 SCCOHTs and in a series of 122 tumors that could mimic SCCOHT morphologically: 9 juvenile granulosa cell tumors, 47 adult granulosa cell tumors, 33 high-grade ovarian serous carcinomas, 9 desmoplastic round cell tumors, 13 Ewing sarcomas (5 from the pelvis and 8 from soft tissues), 1 round cell sarcoma associated with CIC-DUX4 translocation from soft tissue (thigh), 1 case of high-grade endometrial stromal sarcoma of the ovary, and 9 melanomas. 26135561 2015
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 AlteredExpression group BEFREE We performed a detailed immunohistochemical analysis to investigate ETV4 expression in CIC-rearranged undifferentiated round-cell sarcomas and their potential mimics (especially Ewing sarcomas). 27562494 2016
Entrez Id: 23152
Gene Symbol: CIC
CIC
0.100 GeneticVariation group BEFREE We recognized the tumor as a genetically distinct variant of CIC-rearranged sarcomas with a novel NUTM2A-CIC fusion. 28188754 2017