Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
0.050 AlteredExpression group BEFREE p53 missense but not truncation mutations are associated with low levels of p21(CIP1/WAF1) mRNA expression in primary human sarcomas. 11401317 2001
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
0.050 Biomarker group BEFREE The role of DNA mismatch repair proteins (hMSH2 and hMLH1) and p21(waf1) in pediatric tumor responses to chemotherapy and irradiation is described in the present study of 23 pediatric solid cancers (4 wilms' tumors, 9 neuroblastomas, 3 hepatoblastomas, 3 lymphomas and 4 sarcomas) using immunohistochemical methods. 11496300 2001
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
0.050 AlteredExpression group BEFREE We examined the effect of overexpression of p21(waf1) on cytotoxicity of paclitaxel, a microtubule stabilizer, using a tetracycline-inducible expression system in human sarcoma cells (SaOs-2) that lack both functional retinoblastoma protein and p53. 10347252 1999
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
0.050 Biomarker group BEFREE MDM2 is a wild-p53 inducible protein which may form a complex with p53, abrogating its function, as has been found in human sarcomas and other malignancies. p21WAF1/CIP1 is another protein inducible by wild-type p53, involved in inhibiting cell-cycle progression, through binding to cyclin/cyclin-dependent-kinase complexes. 8943816 1996
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
0.050 GeneticVariation group BEFREE To test the hypothesis that primary human tumors have mutations in the CIP1/WAF1 gene which propagates the carcinogenic process, we examined primary breast and sarcoma tumor specimens for alterations in the CIP1/WAF1 gene. 7655464 1995