Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10413
Gene Symbol: YAP1
YAP1
0.070 Biomarker group BEFREE In contrast, radiation-induced sarcomas and KrasG12Dp53-/- sarcomas did not harbor recurrent oncogenic mutations, rather they exhibited amplifications of specific oncogenes: Kras and Myc in KrasG12Dp53-/- sarcomas, and Met and Yap1 for radiation-induced sarcomas. 31112524 2019
Entrez Id: 10413
Gene Symbol: YAP1
YAP1
0.070 Biomarker group BEFREE YAP1 enhances NF-κB-dependent and independent effects on clock-mediated unfolded protein responses and autophagy in sarcoma. 30382078 2018
Entrez Id: 10413
Gene Symbol: YAP1
YAP1
0.070 AlteredExpression group BEFREE TAZ and YAP are transcriptional coactivators negatively regulated by the Hippo pathway that have emerged as key oncoproteins in several cancers including sarcomas. 30167083 2018
Entrez Id: 10413
Gene Symbol: YAP1
YAP1
0.070 Biomarker group BEFREE Using autochthonous mouse models and whole genome analyses, we found that YAP1 was constitutively active in some sarcomas due to epigenetic silencing of its inhibitor angiomotin (AMOT). 29490948 2018
Entrez Id: 10413
Gene Symbol: YAP1
YAP1
0.070 GeneticVariation group BEFREE In the absence of Kras mutations, injury of the muscle with global deletion of p53 results in sarcomas with amplification of chromosomal regions encompassing the Met or Yap1 gene. 30333301 2018
Entrez Id: 10413
Gene Symbol: YAP1
YAP1
0.070 AlteredExpression group BEFREE Verteporfin decreases colony formation in soft agar as well as CTGF expression in sarcoma cell lines harboring activated TAZ and YAP. 27129148 2016
Entrez Id: 10413
Gene Symbol: YAP1
YAP1
0.070 Biomarker group BEFREE Also copy number gains of YAP1 and other Hippo members occur at low frequencies but the most likely cause of perturbed Hippo signalling in sarcoma is the cross-talk with commonly mutated cancer genes such as KRAS, PIK3CA, CTNNB1 or FBXW7. 26050962 2015