Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.050 Biomarker group BEFREE Targeting pediatric sarcoma with a bispecific ligand immunotoxin targeting urokinase and epidermal growth factor receptors. 29552283 2018
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.050 Biomarker group BEFREE These studies report a new drug for sarcomas that simultaneously targets both tumor and tumor neovasculature. eBAT is a bispecific angiotoxin consisting of truncated, deimmunized <i>Pseudomonas</i> exotoxin fused to EGF and the amino terminal fragment of urokinase. 28193671 2017
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.050 AlteredExpression group BEFREE Mechanistically, ANO1 knockdown or pharmacological inhibition of its chloride-channel activity reduced EGF receptor (EGFR) and calmodulin-dependent protein kinase II (CAMKII) signaling, which subsequently attenuated AKT, v-src sarcoma viral oncogene homolog (SRC), and extracellular signal-regulated kinase (ERK) activation in vitro and in vivo. 23431153 2013
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.050 AlteredExpression group BEFREE The results suggest ligand activity in the Fas death pathway correlates with EGF transcription in sarcomas. 18506556 2008
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.050 AlteredExpression group BEFREE To determine a role for ligand-mediated receptor activation in sarcoma progression, the relative expression and function of EGF-R, IGF-I-R, and several other molecular determinants implicated in the progression of mesenchymal neoplasms were evaluated in human sarcoma cells established from surgical specimens of primary and metastatic tumors. mRNA blot analyses demonstrated the expression of c-Met, p53, and MDM2-specific transcripts. 9458358 1998