Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.100 Biomarker group BEFREE Herein, we report the clinical, histopathologic, and molecular findings of a germline DICER1-associated ovarian sarcoma in a 5-year-old female, a somatic DICER1-associated metastatic peritoneal sarcoma in a 16-year-old female, and a somatic DICER1-associated primary intracranial sarcoma in a 4-year-old male. 31537896 2020
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.100 Biomarker group BEFREE Several central nervous system (CNS) manifestations have also been defined, including metastases of PPB to the cerebrum, pituitary blastoma, pineoblastoma, ciliary body medulloepithelioma, and most recently primary DICER1-associated CNS sarcomas and ETMR-like infantile cerebellar embryonal tumor. 30953130 2020
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.100 GeneticVariation group BEFREE Our cases provide further evidence of the link between primary intracranial sarcoma and DICER1 mutation which may form a distinct entity. 31487013 2019
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.100 GeneticVariation group BEFREE In addition to the germ-line DICER1 deletion, somatic DICER1 RNase IIIb mutations were found in the CBME (c.5437G > A, p.E1813K), pCN (c.5425G > A, p.G1809R), and sarcoma (c.5125G > A, p.D1709N). 29315962 2018
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.100 Biomarker group BEFREE The identified combination of genetic events indicates a relationship between the intracranial tumors analyzed and DICER1 predisposition syndrome-associated sarcomas such as embryonal rhabdomyosarcoma or the recently described group of anaplastic sarcomas of the kidney. 29881993 2018
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.100 GeneticVariation group BEFREE We show that deleterious DICER1 mutations underlie the genetic basis of only a small fraction of sarcomas, in particular ERMS of the urogenital tract. 28524158 2017
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.100 GeneticVariation group BEFREE Germline DICER1 mutations have been described in individuals with pleuropulmonary blastoma (PPB), ovarian Sertoli-Leydig cell tumor (SLCT), sarcomas, multinodular goiter, thyroid carcinoma, cystic nephroma and other neoplastic conditions. 26289771 2016
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.100 GeneticVariation group BEFREE The primary pathology of PPB, epithelial cysts with stromal hyperplasia and risk for progression to a complex primitive sarcoma, is associated with familial heterozygosity and lesion-associated epithelial loss-of-heterozygosity of DICER1. 25978641 2015
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.100 AlteredExpression group BEFREE Using an anti-human monoclonal antibody against Dicer and immunohistochemistry, we compared the expression of Dicer protein among 404 clinically annotated controls and skin tumors consisting of melanocytic nevi (n = 71), a variety of melanomas (n = 223), carcinomas (n = 73) and sarcomas (n = 12). 21698147 2011
Entrez Id: 23405
Gene Symbol: DICER1
DICER1
0.100 AlteredExpression group BEFREE Expression of DICER1 protein was undetectable in the epithelial component of PPB tumors but was retained in the malignant mesenchyme (sarcoma). 19556464 2009