| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | group | BEFREE | Somatic genetic rearrangements that juxtapose the PAX3 DNA binding domain to the transcriptional activation domain of other transcription factors deregulate PAX3 function and contribute to the pathogenesis of the soft tissue cancers alveolar rhabdomyosarcoma and biphenotypic sinonasal sarcoma. | 29730428 | 2018 | ||||
|
0.090 | Biomarker | group | BEFREE | In recent work published in The Journal of Pathology, dependency on a fusion protein was addressed using a model of alveolar rhabdomyosarcomas - a sarcoma subtype with frequent fusion of PAX3 and FOXO1 genes that is associated with poor outcome. | 28378394 | 2017 | ||||
|
0.090 | GeneticVariation | group | BEFREE | The childhood sarcoma, Alveolar Rhabdomyosarcoma (ARMS), is primarily defined by the t(2;13)(q35;q14) translocation, creating the PAX3-FOXO1 fusion protein. | 27588498 | 2016 | ||||
|
0.090 | Biomarker | group | BEFREE | Alternate PAX3-FOXO1 oncogenic fusion in biphenotypic sinonasal sarcoma. | 26355893 | 2016 | ||||
|
0.090 | AlteredExpression | group | BEFREE | Alveolar rhabdomyosarcoma (aRMS) is an aggressive sarcoma of skeletal muscle characterized by expression of the paired box 3-forkhead box protein O1 (PAX3-FOXO1) fusion oncogene. | 24334454 | 2014 | ||||
|
0.090 | AlteredExpression | group | BEFREE | The SNS phenotype is characterized by aberrant expression of genes involved in neuroectodermal and myogenic differentiation, closely simulating the developmental roles of PAX3. | 24859338 | 2014 | ||||
|
0.090 | Biomarker | group | BEFREE | While AHRR has never been implicated in gene fusions before, NCOA2 is the 3'-partner in fusions with MYST3 and ETV6 in leukemias and with PAX3 and HEY1 in sarcomas. | 22337624 | 2012 | ||||
|
0.090 | GeneticVariation | group | BEFREE | Alveolar rhabdomyosarcoma (ARMS) is a soft tissue cancer in which chromosomal translocations generate PAX3-FKHR and PAX7-FKHR gene fusions. | 16645206 | 2006 | ||||
|
0.090 | Biomarker | group | BEFREE | The PAX3-FKHR FISH assay was then applied to a series of cytogenetically characterized pediatric sarcoma cell lines. | 7536457 | 1995 |