Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 Biomarker group BEFREE In this study, we answer these fundamental questions through investigation of the genetic and epigenetic pathways that control the origin of ABCB1 (MDR1) gene activation with acquired multidrug resistance in drug-sensitive human sarcoma (MES-SA cells). 16230402 2005
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 Biomarker group BEFREE Due to these favorable characteristics sarcoma is an attractive target to test the efficacy of MDR1 gene therapy in a clinical setting. 12426490 2002
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 Biomarker group BEFREE We investigated MDR1 activation in MDR variants of a human sarcoma line, some of which express a mutant MDR1, which facilitated the study of allelic gene expression. 12112526 2002
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 AlteredExpression group BEFREE In six sarcomas with mdr1 mRNA expression, five were resistant against doxorubicin and cross-resistant against several other drugs, whereas from eight sarcomas, which lacked detectable mdr1 mRNA, seven were sensitive to doxorubicin and other drugs. 10473106 1999
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 AlteredExpression group BEFREE In this review, an attempt is made to summarise the accuracy of the measurement of MDR1 expression for use in prognosis, as well as in decisions on chemotherapeutic treatment of sarcomas. 8695249 1996
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 AlteredExpression group BEFREE Further studies on drug resistance mechanisms and the role of MDR1 expression in sarcomas have been reported. 7803538 1994
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 AlteredExpression group BEFREE This study confirms that MDR1 overexpression occurs in human sarcomas but is not the principal mechanism of drug-resistance. 7903154 1993
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 AlteredExpression group BEFREE Units of mdr1 expression were defined by reference to drug-sensitive human sarcoma and K562 leukemia cell lines (1 U) and the highly resistant doxorubicin selected leukemia cells K562/R7 (50 U). 1859877 1991