Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | group | BEFREE | In this study, we answer these fundamental questions through investigation of the genetic and epigenetic pathways that control the origin of ABCB1 (MDR1) gene activation with acquired multidrug resistance in drug-sensitive human sarcoma (MES-SA cells). | 16230402 | 2005 | ||||
|
0.080 | Biomarker | group | BEFREE | Due to these favorable characteristics sarcoma is an attractive target to test the efficacy of MDR1 gene therapy in a clinical setting. | 12426490 | 2002 | ||||
|
0.080 | Biomarker | group | BEFREE | We investigated MDR1 activation in MDR variants of a human sarcoma line, some of which express a mutant MDR1, which facilitated the study of allelic gene expression. | 12112526 | 2002 | ||||
|
0.080 | AlteredExpression | group | BEFREE | In six sarcomas with mdr1 mRNA expression, five were resistant against doxorubicin and cross-resistant against several other drugs, whereas from eight sarcomas, which lacked detectable mdr1 mRNA, seven were sensitive to doxorubicin and other drugs. | 10473106 | 1999 | ||||
|
0.080 | AlteredExpression | group | BEFREE | In this review, an attempt is made to summarise the accuracy of the measurement of MDR1 expression for use in prognosis, as well as in decisions on chemotherapeutic treatment of sarcomas. | 8695249 | 1996 | ||||
|
0.080 | AlteredExpression | group | BEFREE | Further studies on drug resistance mechanisms and the role of MDR1 expression in sarcomas have been reported. | 7803538 | 1994 | ||||
|
0.080 | AlteredExpression | group | BEFREE | This study confirms that MDR1 overexpression occurs in human sarcomas but is not the principal mechanism of drug-resistance. | 7903154 | 1993 | ||||
|
0.080 | AlteredExpression | group | BEFREE | Units of mdr1 expression were defined by reference to drug-sensitive human sarcoma and K562 leukemia cell lines (1 U) and the highly resistant doxorubicin selected leukemia cells K562/R7 (50 U). | 1859877 | 1991 |